DNA ligase 1

Intramolecular

A redox-regulated disulphide may form within DNA ligase 1 between cysteines 794 and 846. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7sx5

Structure name

crystal structure of ligase i with nick duplexes containing mismatch a:c

Structure deposition date

2021-11-22

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

P18858

Residue number A

794

Residue number B

846

Peptide name

DNA ligase 1

Ligandability

Cysteine 794 of DNA ligase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.