ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Peptidylglycine alpha-amidating monooxygenase

Intramolecular
Cysteine 114 and cysteine 131
Cysteine 81 and cysteine 126
Cysteine 227 and cysteine 334
Cysteine 47 and cysteine 186
Cysteine 293 and cysteine 315
Cysteine 634 and cysteine 655
Cysteine 702 and cysteine 713
Cysteine 81 and cysteine 131
Cysteine 126 and cysteine 131
Cysteine 81 and cysteine 114
A redox-regulated disulphide may form within Peptidylglycine alpha-amidating monooxygenase between cysteines 114 and 131.

Details

Redox score ?
84
PDB code
3mic
Structure name
oxidized (cu2+) peptidylglycine alpha-hydroxylating monooxygenase (phm) with bound azide obtained by co-crystallization
Structure deposition date
2010-04-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14925
Residue number A
114
Residue number B
131
Peptide name
Peptidylglycine alpha-amidating monooxygenase

Ligandability

Cysteine 114 of Peptidylglycine alpha-amidating monooxygenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 131 of Peptidylglycine alpha-amidating monooxygenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptidylglycine alpha-amidating monooxygenase between cysteines 81 and 126.

Details

Redox score ?
84
PDB code
3mig
Structure name
oxidized (cu2+) peptidylglycine alpha-hydroxylating monooxygenase (phm) with bound nitrite, obtained in the presence of substrate
Structure deposition date
2010-04-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14925
Residue number A
81
Residue number B
126
Peptide name
Peptidylglycine alpha-amidating monooxygenase

Ligandability

Cysteine 81 of Peptidylglycine alpha-amidating monooxygenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of Peptidylglycine alpha-amidating monooxygenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptidylglycine alpha-amidating monooxygenase between cysteines 227 and 334.

Details

Redox score ?
82
PDB code
6ay0
Structure name
crystal structure of h108a peptidylglycine alpha-hydroxylating monooxygenase (phm) soaked with peptide
Structure deposition date
2017-09-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14925
Residue number A
227
Residue number B
334
Peptide name
Peptidylglycine alpha-amidating monooxygenase

Ligandability

Cysteine 227 of Peptidylglycine alpha-amidating monooxygenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 334 of Peptidylglycine alpha-amidating monooxygenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptidylglycine alpha-amidating monooxygenase between cysteines 47 and 186.

Details

Redox score ?
82
PDB code
1sdw
Structure name
reduced (cu+) peptidylglycine alpha-hydroxylating monooxygenase with bound peptide and dioxygen
Structure deposition date
2004-02-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14925
Residue number A
47
Residue number B
186
Peptide name
Peptidylglycine alpha-amidating monooxygenase

Ligandability

Cysteine 47 of Peptidylglycine alpha-amidating monooxygenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of Peptidylglycine alpha-amidating monooxygenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptidylglycine alpha-amidating monooxygenase between cysteines 293 and 315.

Details

Redox score ?
79
PDB code
3mic
Structure name
oxidized (cu2+) peptidylglycine alpha-hydroxylating monooxygenase (phm) with bound azide obtained by co-crystallization
Structure deposition date
2010-04-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14925
Residue number A
293
Residue number B
315
Peptide name
Peptidylglycine alpha-amidating monooxygenase

Ligandability

Cysteine 293 of Peptidylglycine alpha-amidating monooxygenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 315 of Peptidylglycine alpha-amidating monooxygenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptidylglycine alpha-amidating monooxygenase between cysteines 634 and 655.

Details

Redox score ?
75
PDB code
3fw0
Structure name
structure of peptidyl-alpha-hydroxyglycine alpha-amidating lyase (pal) bound to alpha-hydroxyhippuric acid (non- peptidic substrate)
Structure deposition date
2009-01-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14925
Residue number A
634
Residue number B
655
Peptide name
Peptidylglycine alpha-amidating monooxygenase

Ligandability

Cysteine 634 of Peptidylglycine alpha-amidating monooxygenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 655 of Peptidylglycine alpha-amidating monooxygenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptidylglycine alpha-amidating monooxygenase between cysteines 702 and 713.

Details

Redox score ?
71
PDB code
3fvz
Structure name
structure of peptidyl-alpha-hydroxyglycine alpha-amidating lyase (pal)
Structure deposition date
2009-01-16
Thiol separation (Å)
3
Half-sphere exposure sum ?
87
Minimum pKa ?
8
% buried
96
Peptide accession
P14925
Residue number A
702
Residue number B
713
Peptide name
Peptidylglycine alpha-amidating monooxygenase

Ligandability

Cysteine 702 of Peptidylglycine alpha-amidating monooxygenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 713 of Peptidylglycine alpha-amidating monooxygenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptidylglycine alpha-amidating monooxygenase between cysteines 81 and 131. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6ala
Structure name
crystal structure of h108a peptidylglycine alpha-hydroxylating monooxygenase (phm) in complex with citrate
Structure deposition date
2017-08-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14925
Residue number A
81
Residue number B
131
Peptide name
Peptidylglycine alpha-amidating monooxygenase

Ligandability

Cysteine 81 of Peptidylglycine alpha-amidating monooxygenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 131 of Peptidylglycine alpha-amidating monooxygenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptidylglycine alpha-amidating monooxygenase between cysteines 126 and 131. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
3mif
Structure name
oxidized (cu2+) peptidylglycine alpha-hydroxylating monooxygenase (phm) with bound carbon monooxide (co)
Structure deposition date
2010-04-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14925
Residue number A
126
Residue number B
131
Peptide name
Peptidylglycine alpha-amidating monooxygenase

Ligandability

Cysteine 126 of Peptidylglycine alpha-amidating monooxygenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 131 of Peptidylglycine alpha-amidating monooxygenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptidylglycine alpha-amidating monooxygenase between cysteines 81 and 114. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
1sdw
Structure name
reduced (cu+) peptidylglycine alpha-hydroxylating monooxygenase with bound peptide and dioxygen
Structure deposition date
2004-02-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14925
Residue number A
81
Residue number B
114
Peptide name
Peptidylglycine alpha-amidating monooxygenase

Ligandability

Cysteine 81 of Peptidylglycine alpha-amidating monooxygenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of Peptidylglycine alpha-amidating monooxygenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: