ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cadherin-2

Intramolecular
Cysteine 32 and cysteine 63
Cysteine 613 and cysteine 701
A redox-regulated disulphide may form within Cadherin-2 between cysteines 32 and 63.

Details

Redox score ?
88
PDB code
1op4
Structure name
solution structure of neural cadherin prodomain
Structure deposition date
2003-03-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
28
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15116
Residue number A
32
Residue number B
63
Peptide name
Cadherin-2

Ligandability

Cysteine 32 of Cadherin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 63 of Cadherin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cadherin-2 between cysteines 613 and 701 (454 and 542 respectively in this structure).

Details

Redox score ?
83
PDB code
3q2w
Structure name
crystal structure of mouse n-cadherin ectodomain
Structure deposition date
2010-12-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
P15116
Residue number A
613
Residue number B
701
Peptide name
Cadherin-2

Ligandability

Cysteine 613 of Cadherin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 701 of Cadherin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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