a tool for identifying drug-targetable redox-active disulphides

Histidine decarboxylase

Intramolecular

Cysteine 101 and cysteine 112

A redox-regulated disulphide may form within Histidine decarboxylase between cysteines 101 and 112.

Details

Redox score ?

62

PDB code

Structure name

human histidine decarboxylase complex with histidine methyl ester (hme)

Structure deposition date

2012-03-06

Thiol separation (Å)

5

Half-sphere exposure sum ?

92

Minimum pK_a ?

8

% buried

100

Peptide accession

Residue number A

101

Residue number B

112

Peptide name

Histidine decarboxylase

Ligandability

Cysteine 101 of Histidine decarboxylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 112 of Histidine decarboxylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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