ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Erythropoietin receptor

Intermolecular
Cysteine 125 of Tyrosine-protein kinase JAK2 and cysteine 314 L
Intramolecular
Cysteine 52 and cysteine 62
Cysteine 91 and cysteine 107
Cysteine 62 and cysteine 107
Cysteine 52 and cysteine 107
Cysteine 62 and cysteine 91
Cysteine 52 and cysteine 91
A redox-regulated disulphide may form between cysteine 125 of Tyrosine-protein kinase JAK2 and cysteine 314 of Erythropoietin receptor. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
6e2q
Structure name
structure of human jak2 ferm/sh2 in complex with erythropoietin receptor
Structure deposition date
2018-07-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
86
Peptide A name
Tyrosine-protein kinase JAK2
Peptide B name
Erythropoietin receptor
Peptide A accession
O60674
Peptide B accession
P19235
Peptide A residue number
125
Peptide B residue number
314

Ligandability

Cysteine 125 of Tyrosine-protein kinase JAK2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 314 of Erythropoietin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Erythropoietin receptor between cysteines 52 and 62 (28 and 38 respectively in this structure).

Details

Redox score ?
79
PDB code
6moj
Structure name
dimeric darpin a_angle_r5 complex with epor
Structure deposition date
2018-10-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
P19235
Residue number A
52
Residue number B
62
Peptide name
Erythropoietin receptor

Ligandability

Cysteine 52 of Erythropoietin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 62 of Erythropoietin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Erythropoietin receptor between cysteines 91 and 107 (67 and 83 respectively in this structure).

Details

Redox score ?
67
PDB code
2jix
Structure name
crystal structure of abt-007 fab fragment with the soluble domain of epo receptor
Structure deposition date
2007-07-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
13
% buried
nan
Peptide accession
P19235
Residue number A
91
Residue number B
107
Peptide name
Erythropoietin receptor

Ligandability

Cysteine 91 of Erythropoietin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of Erythropoietin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Erythropoietin receptor between cysteines 62 and 107 (38 and 83 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
2jix
Structure name
crystal structure of abt-007 fab fragment with the soluble domain of epo receptor
Structure deposition date
2007-07-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
13
% buried
nan
Peptide accession
P19235
Residue number A
62
Residue number B
107
Peptide name
Erythropoietin receptor

Ligandability

Cysteine 62 of Erythropoietin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of Erythropoietin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Erythropoietin receptor between cysteines 52 and 107 (28 and 83 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6moe
Structure name
monomeric darpin e2 complex with epor
Structure deposition date
2018-10-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P19235
Residue number A
52
Residue number B
107
Peptide name
Erythropoietin receptor

Ligandability

Cysteine 52 of Erythropoietin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of Erythropoietin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Erythropoietin receptor between cysteines 62 and 91 (38 and 67 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6moe
Structure name
monomeric darpin e2 complex with epor
Structure deposition date
2018-10-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P19235
Residue number A
62
Residue number B
91
Peptide name
Erythropoietin receptor

Ligandability

Cysteine 62 of Erythropoietin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 of Erythropoietin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Erythropoietin receptor between cysteines 52 and 91 (28 and 67 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6moh
Structure name
dimeric darpin c_r3 complex with epor
Structure deposition date
2018-10-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P19235
Residue number A
52
Residue number B
91
Peptide name
Erythropoietin receptor

Ligandability

Cysteine 52 of Erythropoietin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 of Erythropoietin receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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