ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Lymphocyte function-associated antigen 3

Intramolecular
Cysteine 131 and cysteine 152
Cysteine 161 and cysteine 169
A redox-regulated disulphide may form within Lymphocyte function-associated antigen 3 between cysteines 131 and 152 (112 and 152 respectively in this structure).

Details

Redox score ?
nan
PDB code
1ccz
Structure name
crystal structure of the cd2-binding domain of cd58 (lymphocyte function-associated antigen 3) at 1
Structure deposition date
1999-03-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P19256
Residue number A
131
Residue number B
152
Peptide name
Lymphocyte function-associated antigen 3

Ligandability

Cysteine 131 of Lymphocyte function-associated antigen 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 152 of Lymphocyte function-associated antigen 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 152 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Lymphocyte function-associated antigen 3 between cysteines 161 and 169 (105 and 169 respectively in this structure).

Details

Redox score ?
nan
PDB code
1ccz
Structure name
crystal structure of the cd2-binding domain of cd58 (lymphocyte function-associated antigen 3) at 1
Structure deposition date
1999-03-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
37
Minimum pKa ?
nan
% buried
nan
Peptide accession
P19256
Residue number A
161
Residue number B
169
Peptide name
Lymphocyte function-associated antigen 3

Ligandability

Cysteine 161 of Lymphocyte function-associated antigen 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 169 of Lymphocyte function-associated antigen 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 105 has been assigned to correct residue.
Cysteine 169 in protein B could not be asigned to a Uniprot residue.
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