ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Vascular cell adhesion protein 1

Intramolecular
Cysteine 52 and cysteine 99
Cysteine 137 and cysteine 195
Cysteine 47 and cysteine 95
A redox-regulated disulphide may form within Vascular cell adhesion protein 1 between cysteines 52 and 99 (28 and 75 respectively in this structure).

Details

Redox score ?
89
PDB code
1vca
Structure name
crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1
Structure deposition date
1995-03-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P19320
Residue number A
52
Residue number B
99
Peptide name
Vascular cell adhesion protein 1

Ligandability

Cysteine 52 of Vascular cell adhesion protein 1

Cysteine 99 of Vascular cell adhesion protein 1

A redox-regulated disulphide may form within Vascular cell adhesion protein 1 between cysteines 137 and 195 (113 and 171 respectively in this structure).

Details

Redox score ?
82
PDB code
1vca
Structure name
crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1
Structure deposition date
1995-03-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P19320
Residue number A
137
Residue number B
195
Peptide name
Vascular cell adhesion protein 1

Ligandability

Cysteine 137 of Vascular cell adhesion protein 1

Cysteine 195 of Vascular cell adhesion protein 1

A redox-regulated disulphide may form within Vascular cell adhesion protein 1 between cysteines 47 and 95 (23 and 71 respectively in this structure).

Details

Redox score ?
82
PDB code
1vsc
Structure name
vcam-1
Structure deposition date
1995-04-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P19320
Residue number A
47
Residue number B
95
Peptide name
Vascular cell adhesion protein 1

Ligandability

Cysteine 47 of Vascular cell adhesion protein 1

Cysteine 95 of Vascular cell adhesion protein 1

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