a tool for identifying drug-targetable redox-active disulphides

Trichosurin

Intramolecular

Cysteine 87 and cysteine 180

A redox-regulated disulphide may form within Trichosurin between cysteines 87 and 180 (73 and 166 respectively in this structure).

Details

Redox score ?

91

PDB code

Structure name

crystal structure of the possum milk whey lipocalin trichosurin at ph 4

Structure deposition date

2007-09-14

Thiol separation (Å)

2

Half-sphere exposure sum ?

nan

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

87

Residue number B

180

Peptide name

Trichosurin

Ligandability

Cysteine 87 of Trichosurin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Trichosurin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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