ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Glutathione hydrolase 1 proenzyme

Intramolecular
Cysteine 50 and cysteine 74
Cysteine 192 and cysteine 196
A redox-regulated disulphide may form within Glutathione hydrolase 1 proenzyme between cysteines 50 and 74.

Details

Redox score ?
78
PDB code
7lbc
Structure name
structure of human ggt1 in complex with lnt2-65 compound
Structure deposition date
2021-01-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P19440
Residue number A
50
Residue number B
74
Peptide name
Glutathione hydrolase 1 proenzyme

Ligandability

Cysteine 50 of Glutathione hydrolase 1 proenzyme

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 74 of Glutathione hydrolase 1 proenzyme

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glutathione hydrolase 1 proenzyme between cysteines 192 and 196.

Details

Redox score ?
75
PDB code
7ld9
Structure name
structure of human ggt1 in complex with abba
Structure deposition date
2021-01-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P19440
Residue number A
192
Residue number B
196
Peptide name
Glutathione hydrolase 1 proenzyme

Ligandability

Cysteine 192 of Glutathione hydrolase 1 proenzyme

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 196 of Glutathione hydrolase 1 proenzyme

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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