ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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General transcription and DNA repair factor IIH helicase subunit XPB

Intramolecular
Cysteine 390 and cysteine 403
Cysteine 197 and cysteine 284
Cysteine 361 and cysteine 403
Cysteine 355 and cysteine 361
Cysteine 512 and cysteine 544
Cysteine 361 and cysteine 390
Cysteine 361 and cysteine 462
A redox-regulated disulphide may form within General transcription and DNA repair factor IIH helicase subunit XPB between cysteines 390 and 403.

Details

Redox score ?
77
PDB code
7nvw
Structure name
tfiih in a pre-translocated state (without adp-bef3)
Structure deposition date
2021-03-16
Thiol separation (Å)
3
Half-sphere exposure sum ?
61
Minimum pKa ?
7
% buried
64
Peptide accession
P19447
Residue number A
390
Residue number B
403
Peptide name
General transcription and DNA repair factor IIH helicase subunit XPB

Ligandability

Cysteine 390 of General transcription and DNA repair factor IIH helicase subunit XPB

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 403 of General transcription and DNA repair factor IIH helicase subunit XPB

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription and DNA repair factor IIH helicase subunit XPB between cysteines 197 and 284. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7nw0
Structure name
rna polymerase ii pre-initiation complex with open promoter dna
Structure deposition date
2021-03-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
80
Peptide accession
P19447
Residue number A
197
Residue number B
284
Peptide name
General transcription and DNA repair factor IIH helicase subunit XPB

Ligandability

Cysteine 197 of General transcription and DNA repair factor IIH helicase subunit XPB

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 284 of General transcription and DNA repair factor IIH helicase subunit XPB

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription and DNA repair factor IIH helicase subunit XPB between cysteines 361 and 403. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7nvw
Structure name
tfiih in a pre-translocated state (without adp-bef3)
Structure deposition date
2021-03-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
7
% buried
75
Peptide accession
P19447
Residue number A
361
Residue number B
403
Peptide name
General transcription and DNA repair factor IIH helicase subunit XPB

Ligandability

Cysteine 361 of General transcription and DNA repair factor IIH helicase subunit XPB

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 403 of General transcription and DNA repair factor IIH helicase subunit XPB

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription and DNA repair factor IIH helicase subunit XPB between cysteines 355 and 361. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7nvz
Structure name
rna polymerase ii pre-initiation complex with closed promoter dna in distal position
Structure deposition date
2021-03-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
94
Peptide accession
P19447
Residue number A
355
Residue number B
361
Peptide name
General transcription and DNA repair factor IIH helicase subunit XPB

Ligandability

Cysteine 355 of General transcription and DNA repair factor IIH helicase subunit XPB

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 361 of General transcription and DNA repair factor IIH helicase subunit XPB

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription and DNA repair factor IIH helicase subunit XPB between cysteines 512 and 544. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
4ern
Structure name
crystal structure of the c-terminal domain of human xpb/ercc-3 excision repair protein at 1
Structure deposition date
2012-04-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
100
Peptide accession
P19447
Residue number A
512
Residue number B
544
Peptide name
General transcription and DNA repair factor IIH helicase subunit XPB

Ligandability

Cysteine 512 of General transcription and DNA repair factor IIH helicase subunit XPB

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 544 of General transcription and DNA repair factor IIH helicase subunit XPB

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription and DNA repair factor IIH helicase subunit XPB between cysteines 361 and 390. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
7nvz
Structure name
rna polymerase ii pre-initiation complex with closed promoter dna in distal position
Structure deposition date
2021-03-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
13
% buried
90
Peptide accession
P19447
Residue number A
361
Residue number B
390
Peptide name
General transcription and DNA repair factor IIH helicase subunit XPB

Ligandability

Cysteine 361 of General transcription and DNA repair factor IIH helicase subunit XPB

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 390 of General transcription and DNA repair factor IIH helicase subunit XPB

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General transcription and DNA repair factor IIH helicase subunit XPB between cysteines 361 and 462. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
7nvv
Structure name
xpb-containing part of tfiih in a post-translocated state (with adp- bef3)
Structure deposition date
2021-03-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
92
Minimum pKa ?
12
% buried
100
Peptide accession
P19447
Residue number A
361
Residue number B
462
Peptide name
General transcription and DNA repair factor IIH helicase subunit XPB

Ligandability

Cysteine 361 of General transcription and DNA repair factor IIH helicase subunit XPB

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 462 of General transcription and DNA repair factor IIH helicase subunit XPB

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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