ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interferon-induced, double-stranded RNA-activated protein kinase

Intramolecular
Cysteine 116 and cysteine 128
Cysteine 128 and cysteine 130
A redox-regulated disulphide may form within Interferon-induced, double-stranded RNA-activated protein kinase between cysteines 116 and 128 (28 and 40 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
1x48
Structure name
solution structure of the second dsrm domain in interferon-induced, double-stranded rna-activated protein kinase
Structure deposition date
2005-05-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
8
Peptide accession
Q03963
Residue number A
116
Residue number B
128
Peptide name
Interferon-induced, double-stranded RNA-activated protein kinase

Ligandability

Cysteine 116 of Interferon-induced, double-stranded RNA-activated protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 128 of Interferon-induced, double-stranded RNA-activated protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon-induced, double-stranded RNA-activated protein kinase between cysteines 128 and 130 (40 and 42 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
1x48
Structure name
solution structure of the second dsrm domain in interferon-induced, double-stranded rna-activated protein kinase
Structure deposition date
2005-05-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
32
Peptide accession
Q03963
Residue number A
128
Residue number B
130
Peptide name
Interferon-induced, double-stranded RNA-activated protein kinase

Ligandability

Cysteine 128 of Interferon-induced, double-stranded RNA-activated protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 130 of Interferon-induced, double-stranded RNA-activated protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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