ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Inter-alpha-trypsin inhibitor heavy chain H1

Intramolecular
Cysteine 244 and cysteine 247
Cysteine 268 and cysteine 540
A redox-regulated disulphide may form within Inter-alpha-trypsin inhibitor heavy chain H1 between cysteines 244 and 247.

Details

Redox score ?
85
PDB code
6fpz
Structure name
inter-alpha-inhibitor heavy chain 1, d298a
Structure deposition date
2018-02-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
30
Minimum pKa ?
nan
% buried
nan
Peptide accession
P19827
Residue number A
244
Residue number B
247
Peptide name
Inter-alpha-trypsin inhibitor heavy chain H1

Ligandability

Cysteine 244 of Inter-alpha-trypsin inhibitor heavy chain H1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 247 of Inter-alpha-trypsin inhibitor heavy chain H1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inter-alpha-trypsin inhibitor heavy chain H1 between cysteines 268 and 540.

Details

Redox score ?
83
PDB code
6fpz
Structure name
inter-alpha-inhibitor heavy chain 1, d298a
Structure deposition date
2018-02-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P19827
Residue number A
268
Residue number B
540
Peptide name
Inter-alpha-trypsin inhibitor heavy chain H1

Ligandability

Cysteine 268 of Inter-alpha-trypsin inhibitor heavy chain H1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 540 of Inter-alpha-trypsin inhibitor heavy chain H1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: