ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Bile salt-activated lipase

Intramolecular
Cysteine 266 and cysteine 277
Cysteine 84 and cysteine 100
A redox-regulated disulphide may form within Bile salt-activated lipase between cysteines 266 and 277 (246 and 257 respectively in this structure).

Details

Redox score ?
84
PDB code
1f6w
Structure name
structure of the catalytic domain of human bile salt activated lipase
Structure deposition date
2000-06-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P19835
Residue number A
266
Residue number B
277
Peptide name
Bile salt-activated lipase

Ligandability

Cysteine 266 of Bile salt-activated lipase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 277 of Bile salt-activated lipase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bile salt-activated lipase between cysteines 84 and 100 (64 and 80 respectively in this structure).

Details

Redox score ?
81
PDB code
1jmy
Structure name
truncated recombinant human bile salt stimulated lipase
Structure deposition date
2001-07-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P19835
Residue number A
84
Residue number B
100
Peptide name
Bile salt-activated lipase

Ligandability

Cysteine 84 of Bile salt-activated lipase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of Bile salt-activated lipase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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