Nuclear factor NF-kappa-B p105 subunit
Intermolecular
Cysteine 32 of Thioredoxin and cysteine 61 L
Intramolecular
Cysteine 118 and cysteine 123
1mdi A 32 B 7
A redox-regulated disulphide may form between cysteine 32 of Thioredoxin and cysteine 61 of Nuclear factor NF-kappa-B p105 subunit (32 and 7 respectively in this structure).
Details
Redox score ?
88
PDB code
1mdi
Structure name
high resolution solution nmr structure of mixed disulfide intermediate between mutant human thioredoxin and a 13 residue peptide comprising its target site in human nfkb
Structure deposition date
1995-02-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide A name
Thioredoxin
Peptide B name
Nuclear factor NF-kappa-B p105 subunit
Peptide A accession
P10599
Peptide B accession
P19838
Peptide A residue number
32
Peptide B residue number
61
Ligandability
Cysteine 32 of Thioredoxin
Cysteine 61 of Nuclear factor NF-kappa-B p105 subunit
1svc P 119 P 124
A redox-regulated disulphide may form within Nuclear factor NF-kappa-B p105 subunit between cysteines 118 and 123 (119 and 124 respectively in this structure).
Details
Redox score ?
77
PDB code
1svc
Structure name
nfkb p50 homodimer bound to dna
Structure deposition date
1995-11-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
8
% buried
68
Peptide accession
P19838
Residue number A
118
Residue number B
123
Peptide name
Nuclear factor NF-kappa-B p105 subunit
Ligandability
Cysteine 118 of Nuclear factor NF-kappa-B p105 subunit
Cysteine 123 of Nuclear factor NF-kappa-B p105 subunit
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