ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Myeloid cell surface antigen CD33

Intermolecular
Cysteine 36 and cysteine 36
Intramolecular
Cysteine 41 and cysteine 101
Cysteine 163 and cysteine 212
Cysteine 36 and cysteine 169
A redox-regulated disulphide may form between two units of Myeloid cell surface antigen CD33 at cysteines 36 and 36.

Details

Redox score ?
81
PDB code
6d49
Structure name
cell surface receptor in complex with ligand at 1
Structure deposition date
2018-04-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide A name
Myeloid cell surface antigen CD33
Peptide B name
Myeloid cell surface antigen CD33
Peptide A accession
P20138
Peptide B accession
P20138
Peptide A residue number
36
Peptide B residue number
36

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Myeloid cell surface antigen CD33 between cysteines 41 and 101.

Details

Redox score ?
86
PDB code
5j06
Structure name
structure of the immune receptor cd33 in complex with 3'-sialyllactose
Structure deposition date
2016-03-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20138
Residue number A
41
Residue number B
101
Peptide name
Myeloid cell surface antigen CD33

Ligandability

Cysteine 41 of Myeloid cell surface antigen CD33

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of Myeloid cell surface antigen CD33

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Myeloid cell surface antigen CD33 between cysteines 163 and 212.

Details

Redox score ?
81
PDB code
5ihb
Structure name
structure of the immune receptor cd33
Structure deposition date
2016-02-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20138
Residue number A
163
Residue number B
212
Peptide name
Myeloid cell surface antigen CD33

Ligandability

Cysteine 163 of Myeloid cell surface antigen CD33

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 212 of Myeloid cell surface antigen CD33

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Myeloid cell surface antigen CD33 between cysteines 36 and 169.

Details

Redox score ?
81
PDB code
5j0b
Structure name
structure of the immune receptor cd33 in complex with 6'-sialyllactose
Structure deposition date
2016-03-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20138
Residue number A
36
Residue number B
169
Peptide name
Myeloid cell surface antigen CD33

Ligandability

Cysteine 36 of Myeloid cell surface antigen CD33

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 169 of Myeloid cell surface antigen CD33

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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