ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Azurocidin

Intramolecular
Cysteine 149 and cysteine 207
Cysteine 180 and cysteine 186
Cysteine 52 and cysteine 68
Cysteine 197 and cysteine 222
A redox-regulated disulphide may form within Azurocidin between cysteines 149 and 207 (123 and 181 respectively in this structure).

Details

Redox score ?
86
PDB code
1ae5
Structure name
human heparin binding protein
Structure deposition date
1997-03-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20160
Residue number A
149
Residue number B
207
Peptide name
Azurocidin

Ligandability

Cysteine 149 of Azurocidin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 207 of Azurocidin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Azurocidin between cysteines 180 and 186 (154 and 160 respectively in this structure).

Details

Redox score ?
84
PDB code
1fy1
Structure name
[r23s,f25e]hbp, a mutant of human heparin binding protein (cap37)
Structure deposition date
2000-09-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20160
Residue number A
180
Residue number B
186
Peptide name
Azurocidin

Ligandability

Cysteine 180 of Azurocidin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of Azurocidin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Azurocidin between cysteines 52 and 68 (26 and 42 respectively in this structure).

Details

Redox score ?
80
PDB code
1a7s
Structure name
atomic resolution structure of hbp
Structure deposition date
1998-03-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20160
Residue number A
52
Residue number B
68
Peptide name
Azurocidin

Ligandability

Cysteine 52 of Azurocidin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 68 of Azurocidin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Azurocidin between cysteines 197 and 222 (171 and 196 respectively in this structure).

Details

Redox score ?
79
PDB code
1fy3
Structure name
[g175q]hbp, a mutant of human heparin binding protein (cap37)
Structure deposition date
2000-09-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20160
Residue number A
197
Residue number B
222
Peptide name
Azurocidin

Ligandability

Cysteine 197 of Azurocidin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 222 of Azurocidin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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