a tool for identifying drug-targetable redox-active disulphides

TATA-box-binding protein

Intermolecular

Cysteine 370 of Transcription factor IIIB 50 kDa subunit and cysteine 262

A redox-regulated disulphide may form between cysteine 370 of Transcription factor IIIB 50 kDa subunit and cysteine 262 of TATA-box-binding protein. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

39

PDB code

Structure name

tfiiib -tbp/brf2/dna and sant domain of bdp1-

Structure deposition date

2017-02-24

Thiol separation (Å)

10

Half-sphere exposure sum ?

54

Minimum pK_a ?

9

% buried

58

Peptide A name

Transcription factor IIIB 50 kDa subunit

Peptide B name

TATA-box-binding protein

Peptide A accession

Peptide B accession

Peptide A residue number

370

Peptide B residue number

262

Ligandability

Cysteine 370 of Transcription factor IIIB 50 kDa subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 262 of TATA-box-binding protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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