ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Tumor necrosis factor receptor superfamily member 1B

Intramolecular
Cysteine 185 and cysteine 200
Cysteine 164 and cysteine 179
Cysteine 143 and cysteine 161
Cysteine 78 and cysteine 93
Cysteine 54 and cysteine 67
Cysteine 40 and cysteine 53
Cysteine 57 and cysteine 75
Cysteine 96 and cysteine 110
Cysteine 120 and cysteine 137
Cysteine 126 and cysteine 134
More...
Cysteine 100 and cysteine 118
Cysteine 120 and cysteine 134
Cysteine 134 and cysteine 137
Cysteine 120 and cysteine 126
Cysteine 126 and cysteine 137
Cysteine 40 and cysteine 54
Cysteine 143 and cysteine 179
Cysteine 53 and cysteine 54
Cysteine 143 and cysteine 164
Cysteine 40 and cysteine 67
Cysteine 161 and cysteine 179
Cysteine 78 and cysteine 96
Cysteine 78 and cysteine 110
Cysteine 118 and cysteine 137
Cysteine 57 and cysteine 78
Cysteine 53 and cysteine 67
Cysteine 100 and cysteine 137
Cysteine 57 and cysteine 93
Cysteine 118 and cysteine 134
Cysteine 161 and cysteine 164
Cysteine 93 and cysteine 96
Cysteine 118 and cysteine 120
Cysteine 110 and cysteine 118
Cysteine 57 and cysteine 67
Cysteine 100 and cysteine 134
Cysteine 100 and cysteine 120
Cysteine 118 and cysteine 126
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 185 and 200 (163 and 178 respectively in this structure).

Details

Redox score ?
93
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
185
Residue number B
200
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 185 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 200 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 164 and 179 (142 and 157 respectively in this structure).

Details

Redox score ?
88
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
164
Residue number B
179
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 164 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 179 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 143 and 161 (121 and 139 respectively in this structure).

Details

Redox score ?
88
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
143
Residue number B
161
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 143 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 161 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 78 and 93 (56 and 71 respectively in this structure).

Details

Redox score ?
87
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
78
Residue number B
93
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 78 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 93 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 54 and 67 (32 and 45 respectively in this structure).

Details

Redox score ?
87
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
54
Residue number B
67
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 54 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 67 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 40 and 53 (18 and 31 respectively in this structure).

Details

Redox score ?
87
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
39
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
40
Residue number B
53
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 40 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 53 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 57 and 75 (35 and 53 respectively in this structure).

Details

Redox score ?
86
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
57
Residue number B
75
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 57 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 75 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 96 and 110 (74 and 88 respectively in this structure).

Details

Redox score ?
85
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
96
Residue number B
110
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 96 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 110 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 120 and 137 (98 and 115 respectively in this structure).

Details

Redox score ?
85
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
120
Residue number B
137
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 120 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 137 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 126 and 134 (104 and 112 respectively in this structure).

Details

Redox score ?
83
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
126
Residue number B
134
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 126 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 134 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 100 and 118 (78 and 96 respectively in this structure).

Details

Redox score ?
82
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
100
Residue number B
118
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 100 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 118 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 120 and 134 (98 and 112 respectively in this structure).

Details

Redox score ?
77
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
3
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
120
Residue number B
134
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 120 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 134 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 134 and 137 (112 and 115 respectively in this structure).

Details

Redox score ?
74
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
134
Residue number B
137
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 134 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 137 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 120 and 126 (98 and 104 respectively in this structure).

Details

Redox score ?
71
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
120
Residue number B
126
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 120 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 126 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 126 and 137 (104 and 115 respectively in this structure).

Details

Redox score ?
61
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
126
Residue number B
137
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 126 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 137 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 40 and 54 (18 and 32 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
7
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
40
Residue number B
54
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 40 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 54 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 143 and 179 (121 and 157 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
143
Residue number B
179
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 143 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 179 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 53 and 54 (31 and 32 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
7
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
53
Residue number B
54
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 53 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 54 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 143 and 164 (121 and 142 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
143
Residue number B
164
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 143 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 164 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 40 and 67 (18 and 45 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
40
Residue number B
67
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 40 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 67 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 161 and 179 (139 and 157 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
161
Residue number B
179
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 161 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 179 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 78 and 96 (56 and 74 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
78
Residue number B
96
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 78 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 96 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 78 and 110 (56 and 88 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
78
Residue number B
110
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 78 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 110 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 118 and 137 (96 and 115 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
118
Residue number B
137
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 118 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 137 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 57 and 78 (35 and 56 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
57
Residue number B
78
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 57 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 78 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 53 and 67 (31 and 45 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
53
Residue number B
67
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 53 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 67 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 100 and 137 (78 and 115 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
100
Residue number B
137
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 100 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 137 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 57 and 93 (35 and 71 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
57
Residue number B
93
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 57 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 93 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 118 and 134 (96 and 112 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
118
Residue number B
134
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 118 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 134 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 161 and 164 (139 and 142 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
161
Residue number B
164
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 161 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 164 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 93 and 96 (71 and 74 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
93
Residue number B
96
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 93 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 96 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 118 and 120 (96 and 98 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
118
Residue number B
120
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 118 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 120 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 110 and 118 (88 and 96 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
110
Residue number B
118
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 110 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 118 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 57 and 67 (35 and 45 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
57
Residue number B
67
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 57 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 67 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 100 and 134 (78 and 112 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
100
Residue number B
134
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 100 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 134 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 100 and 120 (78 and 98 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
100
Residue number B
120
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 100 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 120 of Tumor necrosis factor receptor superfamily member 1B

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 1B between cysteines 118 and 126 (96 and 104 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
3alq
Structure name
crystal structure of tnf-tnfr2 complex
Structure deposition date
2010-08-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20333
Residue number A
118
Residue number B
126
Peptide name
Tumor necrosis factor receptor superfamily member 1B

Ligandability

Cysteine 118 of Tumor necrosis factor receptor superfamily member 1B

Cysteine 126 of Tumor necrosis factor receptor superfamily member 1B

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