ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ras-related protein Rab-4A

Intramolecular
Cysteine 124 and cysteine 170
A redox-regulated disulphide may form within Ras-related protein Rab-4A between cysteines 124 and 170 (121 and 167 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
2bme
Structure name
high resolution structure of gppnhp-bound human rab4a
Structure deposition date
2005-03-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
91
Minimum pKa ?
12
% buried
100
Peptide accession
P20338
Residue number A
124
Residue number B
170
Peptide name
Ras-related protein Rab-4A

Ligandability

Cysteine 124 of Ras-related protein Rab-4A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 170 of Ras-related protein Rab-4A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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