ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Cation-dependent mannose-6-phosphate receptor

Intramolecular
Cysteine 34 and cysteine 80
Cysteine 147 and cysteine 181
Cysteine 134 and cysteine 169
A redox-regulated disulphide may form within Cation-dependent mannose-6-phosphate receptor between cysteines 34 and 80 (6 and 52 respectively in this structure).

Details

Redox score ?
85
PDB code
2rl9
Structure name
crystal structure cation-dependent mannose 6-phosphate receptor at ph 6
Structure deposition date
2007-10-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11456
Residue number A
34
Residue number B
80
Peptide name
Cation-dependent mannose-6-phosphate receptor

Ligandability

Cysteine 34 of Cation-dependent mannose-6-phosphate receptor

Cysteine 80 of Cation-dependent mannose-6-phosphate receptor

A redox-regulated disulphide may form within Cation-dependent mannose-6-phosphate receptor between cysteines 147 and 181 (119 and 153 respectively in this structure).

Details

Redox score ?
85
PDB code
3cy4
Structure name
crystal structure cation-dependent mannose 6-phosphate receptor at ph 7
Structure deposition date
2008-04-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11456
Residue number A
147
Residue number B
181
Peptide name
Cation-dependent mannose-6-phosphate receptor

Ligandability

Cysteine 147 of Cation-dependent mannose-6-phosphate receptor

Cysteine 181 of Cation-dependent mannose-6-phosphate receptor

A redox-regulated disulphide may form within Cation-dependent mannose-6-phosphate receptor between cysteines 134 and 169 (106 and 141 respectively in this structure).

Details

Redox score ?
85
PDB code
1keo
Structure name
twists and turns of the cd-mpr: ligand-bound versus ligand-free receptor
Structure deposition date
2001-11-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11456
Residue number A
134
Residue number B
169
Peptide name
Cation-dependent mannose-6-phosphate receptor

Ligandability

Cysteine 134 of Cation-dependent mannose-6-phosphate receptor

Cysteine 169 of Cation-dependent mannose-6-phosphate receptor

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