Granzyme H
Intermolecular
Cysteine 170 and cysteine 170
Intramolecular
Cysteine 142 and cysteine 208
Cysteine 172 and cysteine 187
Cysteine 49 and cysteine 65
Cysteine 170 and cysteine 172
Cysteine 170 and cysteine 187
4gaw E 165 F 165
A redox-regulated disulphide may form between two units of Granzyme H at cysteines 170 and 170 (165 and 165 respectively in this structure).
Details
Redox score ?
63
PDB code
4gaw
Structure name
crystal structure of active human granzyme h
Structure deposition date
2012-07-25
Thiol separation (Å)
6
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
24
Peptide A name
Granzyme H
Peptide B name
Granzyme H
Peptide A accession
P20718
Peptide B accession
P20718
Peptide A residue number
170
Peptide B residue number
170
Ligandability
3tjv A 137 A 203
A redox-regulated disulphide may form within Granzyme H between cysteines 142 and 208 (137 and 203 respectively in this structure).
Details
Redox score ?
85
PDB code
3tjv
Structure name
crystal structure of human granzyme h with a peptidyl substrate
Structure deposition date
2011-08-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20718
Residue number A
142
Residue number B
208
Peptide name
Granzyme H
Ligandability
Cysteine 142 of Granzyme H
Cysteine 208 of Granzyme H
3tjv A 167 A 182
A redox-regulated disulphide may form within Granzyme H between cysteines 172 and 187 (167 and 182 respectively in this structure).
Details
Redox score ?
81
PDB code
3tjv
Structure name
crystal structure of human granzyme h with a peptidyl substrate
Structure deposition date
2011-08-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20718
Residue number A
172
Residue number B
187
Peptide name
Granzyme H
Ligandability
Cysteine 172 of Granzyme H
Cysteine 187 of Granzyme H
4gaw F 44 F 60
A redox-regulated disulphide may form within Granzyme H between cysteines 49 and 65 (44 and 60 respectively in this structure).
Details
Redox score ?
80
PDB code
4gaw
Structure name
crystal structure of active human granzyme h
Structure deposition date
2012-07-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20718
Residue number A
49
Residue number B
65
Peptide name
Granzyme H
Ligandability
Cysteine 49 of Granzyme H
Cysteine 65 of Granzyme H
4gaw F 165 F 167
A redox-regulated disulphide may form within Granzyme H between cysteines 170 and 172 (165 and 167 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
4gaw
Structure name
crystal structure of active human granzyme h
Structure deposition date
2012-07-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
9
% buried
nan
Peptide accession
P20718
Residue number A
170
Residue number B
172
Peptide name
Granzyme H
Ligandability
Cysteine 170 of Granzyme H
Cysteine 172 of Granzyme H
4gaw H 165 H 182
A redox-regulated disulphide may form within Granzyme H between cysteines 170 and 187 (165 and 182 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
4gaw
Structure name
crystal structure of active human granzyme h
Structure deposition date
2012-07-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
nan
Peptide accession
P20718
Residue number A
170
Residue number B
187
Peptide name
Granzyme H
Ligandability
Cysteine 170 of Granzyme H
Cysteine 187 of Granzyme H
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