a tool for identifying drug-targetable redox-active disulphides

B-cell lymphoma 3 protein

Intramolecular

Cysteine 213 and cysteine 254

A redox-regulated disulphide may form within B-cell lymphoma 3 protein between cysteines 213 and 254 (205 and 246 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

49

PDB code

Structure name

crystal structure of the ankyrin repeat domain of bcl-3: a unique member of the ikappab protein family

Structure deposition date

2001-09-24

Thiol separation (Å)

8

Half-sphere exposure sum ?

67

Minimum pK_a ?

9

% buried

62

Peptide accession

Residue number A

213

Residue number B

254

Peptide name

B-cell lymphoma 3 protein

Ligandability

Cysteine 213 of B-cell lymphoma 3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 254 of B-cell lymphoma 3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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