N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Intramolecular
Cysteine 163 and cysteine 179
Cysteine 317 and cysteine 345
Cysteine 64 and cysteine 69
Cysteine 286 and cysteine 306
Cysteine 61 and cysteine 64
Cysteine 286 and cysteine 317
Cysteine 61 and cysteine 69
1apy A 140 A 156
A redox-regulated disulphide may form within N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase between cysteines 163 and 179 (140 and 156 respectively in this structure).
Details
Redox score ?
85
PDB code
1apy
Structure name
human aspartylglucosaminidase
Structure deposition date
1995-06-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20933
Residue number A
163
Residue number B
179
Peptide name
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Ligandability
Cysteine 163 of N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Cysteine 179 of N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
1apy B 294 B 322
A redox-regulated disulphide may form within N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase between cysteines 317 and 345 (294 and 322 respectively in this structure).
Details
Redox score ?
84
PDB code
1apy
Structure name
human aspartylglucosaminidase
Structure deposition date
1995-06-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20933
Residue number A
317
Residue number B
345
Peptide name
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Ligandability
Cysteine 317 of N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Cysteine 345 of N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
1apy A 41 A 46
A redox-regulated disulphide may form within N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase between cysteines 64 and 69 (41 and 46 respectively in this structure).
Details
Redox score ?
83
PDB code
1apy
Structure name
human aspartylglucosaminidase
Structure deposition date
1995-06-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20933
Residue number A
64
Residue number B
69
Peptide name
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Ligandability
Cysteine 64 of N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Cysteine 69 of N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
1apy D 263 D 283
A redox-regulated disulphide may form within N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase between cysteines 286 and 306 (263 and 283 respectively in this structure).
Details
Redox score ?
78
PDB code
1apy
Structure name
human aspartylglucosaminidase
Structure deposition date
1995-06-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
101
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20933
Residue number A
286
Residue number B
306
Peptide name
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Ligandability
Cysteine 286 of N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Cysteine 306 of N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
1apz C 38 C 41
A redox-regulated disulphide may form within N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase between cysteines 61 and 64 (38 and 41 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
1apz
Structure name
human aspartylglucosaminidase complex with reaction product
Structure deposition date
1995-06-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
98
Minimum pKa ?
13
% buried
nan
Peptide accession
P20933
Residue number A
61
Residue number B
64
Peptide name
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Ligandability
Cysteine 61 of N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Cysteine 64 of N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
1apz B 263 B 294
A redox-regulated disulphide may form within N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase between cysteines 286 and 317 (263 and 294 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
1apz
Structure name
human aspartylglucosaminidase complex with reaction product
Structure deposition date
1995-06-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20933
Residue number A
286
Residue number B
317
Peptide name
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Ligandability
Cysteine 286 of N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Cysteine 317 of N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
1apz A 38 A 46
A redox-regulated disulphide may form within N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase between cysteines 61 and 69 (38 and 46 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
1apz
Structure name
human aspartylglucosaminidase complex with reaction product
Structure deposition date
1995-06-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
13
% buried
nan
Peptide accession
P20933
Residue number A
61
Residue number B
69
Peptide name
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Ligandability
Cysteine 61 of N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Cysteine 69 of N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
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