ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ras GTPase-activating protein 1

Intramolecular
Cysteine 771 and cysteine 876
Cysteine 745 and cysteine 1002
A redox-regulated disulphide may form within Ras GTPase-activating protein 1 between cysteines 771 and 876.

Details

Redox score ?
75
PDB code
1wer
Structure name
ras-gtpase-activating domain of human p120gap
Structure deposition date
1996-11-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
6
% buried
68
Peptide accession
P20936
Residue number A
771
Residue number B
876
Peptide name
Ras GTPase-activating protein 1

Ligandability

Cysteine 771 of Ras GTPase-activating protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 876 of Ras GTPase-activating protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ras GTPase-activating protein 1 between cysteines 745 and 1002. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1wq1
Structure name
ras-rasgap complex
Structure deposition date
1997-07-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
12
% buried
84
Peptide accession
P20936
Residue number A
745
Residue number B
1002
Peptide name
Ras GTPase-activating protein 1

Ligandability

Cysteine 745 of Ras GTPase-activating protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1002 of Ras GTPase-activating protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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