ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Amine oxidase [flavin-containing] A

Intramolecular
Cysteine 321 and cysteine 323
Cysteine 398 and cysteine 406
A redox-regulated disulphide may form within Amine oxidase [flavin-containing] A between cysteines 321 and 323.

Details

Redox score ?
63
PDB code
2bxs
Structure name
human monoamine oxidase a in complex with clorgyline, crystal form b
Structure deposition date
2005-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
9
% buried
88
Peptide accession
P21397
Residue number A
321
Residue number B
323
Peptide name
Amine oxidase [flavin-containing] A

Ligandability

Cysteine 321 of Amine oxidase [flavin-containing] A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 323 of Amine oxidase [flavin-containing] A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amine oxidase [flavin-containing] A between cysteines 398 and 406. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
1o5w
Structure name
the structure basis of specific recognitions for substrates and inhibitors of rat monoamine oxidase a
Structure deposition date
2003-10-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
100
Peptide accession
P21396
Residue number A
398
Residue number B
406
Peptide name
Amine oxidase [flavin-containing] A

Ligandability

Cysteine 398 of Amine oxidase [flavin-containing] A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 406 of Amine oxidase [flavin-containing] A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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