ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sphingosine 1-phosphate receptor 1

Intramolecular
Cysteine 282 and cysteine 287
Cysteine 184 and cysteine 191
Cysteine 56 and cysteine 57
A redox-regulated disulphide may form within Sphingosine 1-phosphate receptor 1 between cysteines 282 and 287.

Details

Redox score ?
88
PDB code
3v2y
Structure name
crystal structure of a lipid g protein-coupled receptor at 2
Structure deposition date
2011-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21453
Residue number A
282
Residue number B
287
Peptide name
Sphingosine 1-phosphate receptor 1

Ligandability

Cysteine 282 of Sphingosine 1-phosphate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 287 of Sphingosine 1-phosphate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sphingosine 1-phosphate receptor 1 between cysteines 184 and 191.

Details

Redox score ?
82
PDB code
3v2y
Structure name
crystal structure of a lipid g protein-coupled receptor at 2
Structure deposition date
2011-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21453
Residue number A
184
Residue number B
191
Peptide name
Sphingosine 1-phosphate receptor 1

Ligandability

Cysteine 184 of Sphingosine 1-phosphate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 191 of Sphingosine 1-phosphate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sphingosine 1-phosphate receptor 1 between cysteines 56 and 57. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
3v2y
Structure name
crystal structure of a lipid g protein-coupled receptor at 2
Structure deposition date
2011-12-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
28
Peptide accession
P21453
Residue number A
56
Residue number B
57
Peptide name
Sphingosine 1-phosphate receptor 1

Ligandability

Cysteine 56 of Sphingosine 1-phosphate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 57 of Sphingosine 1-phosphate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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