ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Alanine--glyoxylate aminotransferase

Intermolecular
Cysteine 84 and cysteine 84
Intramolecular
Cysteine 173 and cysteine 178
A redox-regulated disulphide may form between two units of Alanine--glyoxylate aminotransferase at cysteines 84 and 84. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7ns7
Structure name
human l-alanine:glyoxylate aminotransferase minor allele variant: agxt-mi (p11l-i340m)
Structure deposition date
2021-03-05
Thiol separation (Å)
6
Half-sphere exposure sum ?
86
Minimum pKa ?
14
% buried
100
Peptide A name
Alanine--glyoxylate aminotransferase
Peptide B name
Alanine--glyoxylate aminotransferase
Peptide A accession
P21549
Peptide B accession
P21549
Peptide A residue number
84
Peptide B residue number
84

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Alanine--glyoxylate aminotransferase between cysteines 173 and 178.

Details

Redox score ?
69
PDB code
4i8a
Structure name
alanine-glyoxylate aminotransferase variant s187f
Structure deposition date
2012-12-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
9
% buried
84
Peptide accession
P21549
Residue number A
173
Residue number B
178
Peptide name
Alanine--glyoxylate aminotransferase

Ligandability

Cysteine 173 of Alanine--glyoxylate aminotransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Alanine--glyoxylate aminotransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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