ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Kit ligand

Intramolecular
Cysteine 68 and cysteine 138
Cysteine 29 and cysteine 114
Cysteine 68 and cysteine 163
Cysteine 68 and cysteine 68
A redox-regulated disulphide may form within Kit ligand between cysteines 68 and 138 (43 and 138 respectively in this structure).

Details

Redox score ?
89
PDB code
1scf
Structure name
human recombinant stem cell factor
Structure deposition date
1998-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21583
Residue number A
68
Residue number B
138
Peptide name
Kit ligand

Ligandability

Cysteine 68 of Kit ligand

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 of Kit ligand

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Kit ligand between cysteines 29 and 114 (4 and 89 respectively in this structure).

Details

Redox score ?
85
PDB code
2e9w
Structure name
crystal structure of the extracellular domain of kit in complex with stem cell factor (scf)
Structure deposition date
2007-01-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21583
Residue number A
29
Residue number B
114
Peptide name
Kit ligand

Ligandability

Cysteine 29 of Kit ligand

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of Kit ligand

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Kit ligand between cysteines 68 and 163 (243 and 338 respectively in this structure).

Details

Redox score ?
85
PDB code
1exz
Structure name
structure of stem cell factor
Structure deposition date
2000-05-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21583
Residue number A
68
Residue number B
163
Peptide name
Kit ligand

Ligandability

Cysteine 68 of Kit ligand

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 163 of Kit ligand

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Kit ligand between cysteines 68 and 68 (43 and 138 respectively in this structure).

Details

Redox score ?
85
PDB code
1exz
Structure name
structure of stem cell factor
Structure deposition date
2000-05-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21583
Residue number A
68
Residue number B
68
Peptide name
Kit ligand

Ligandability

Cysteine 68 of Kit ligand

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 68 of Kit ligand

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 138 has been assigned to correct residue.
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