ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Diamine acetyltransferase 1

Intramolecular
Cysteine 120 and cysteine 122
Cysteine 14 and cysteine 54
A redox-regulated disulphide may form within Diamine acetyltransferase 1 between cysteines 120 and 122.

Details

Redox score ?
65
PDB code
3bj7
Structure name
spermine/spermidine n1-acetyltransferase from mouse: crystal structure of a ternary complex reveals solvent-mediated spermine binding
Structure deposition date
2007-12-03
Thiol separation (Å)
5
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
58
Peptide accession
P48026
Residue number A
120
Residue number B
122
Peptide name
Diamine acetyltransferase 1

Ligandability

Cysteine 120 of Diamine acetyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 122 of Diamine acetyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Diamine acetyltransferase 1 between cysteines 14 and 54. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2b4b
Structure name
ssat+coa+be-3-3-3, k6r mutant
Structure deposition date
2005-09-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
70
Peptide accession
P21673
Residue number A
14
Residue number B
54
Peptide name
Diamine acetyltransferase 1

Ligandability

Cysteine 14 of Diamine acetyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 54 of Diamine acetyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: