a tool for identifying drug-targetable redox-active disulphides

Ephrin type-A receptor 1

Intermolecular

Cysteine 969 and cysteine 969

A redox-regulated disulphide may form between two units of Ephrin type-A receptor 1 at cysteines 969 and 969 (959 and 959 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

58

PDB code

Structure name

sam domain of human ephrin type-a receptor 1 (epha1)

Structure deposition date

2009-05-20

Thiol separation (Å)

6

Half-sphere exposure sum ?

59

Minimum pK_a ?

10

% buried

41

Peptide A name

Ephrin type-A receptor 1

Peptide B name

Ephrin type-A receptor 1

Peptide A accession

Peptide B accession

Peptide A residue number

969

Peptide B residue number

969

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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