ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Midkine

Intramolecular
Cysteine 84 and cysteine 116
Cysteine 94 and cysteine 126
Cysteine 37 and cysteine 61
Cysteine 52 and cysteine 74
Cysteine 45 and cysteine 70
A redox-regulated disulphide may form within Midkine between cysteines 84 and 116 (62 and 94 respectively in this structure).

Details

Redox score ?
92
PDB code
1mkc
Structure name
c-terminal domain of midkine
Structure deposition date
1999-03-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21741
Residue number A
84
Residue number B
116
Peptide name
Midkine

Ligandability

Cysteine 84 of Midkine

Cysteine 116 of Midkine

A redox-regulated disulphide may form within Midkine between cysteines 94 and 126 (72 and 104 respectively in this structure).

Details

Redox score ?
91
PDB code
1mkc
Structure name
c-terminal domain of midkine
Structure deposition date
1999-03-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21741
Residue number A
94
Residue number B
126
Peptide name
Midkine

Ligandability

Cysteine 94 of Midkine

Cysteine 126 of Midkine

A redox-regulated disulphide may form within Midkine between cysteines 37 and 61 (15 and 39 respectively in this structure).

Details

Redox score ?
89
PDB code
1mkn
Structure name
n-terminal half of midkine
Structure deposition date
1999-03-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
35
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21741
Residue number A
37
Residue number B
61
Peptide name
Midkine

Ligandability

Cysteine 37 of Midkine

Cysteine 61 of Midkine

A redox-regulated disulphide may form within Midkine between cysteines 52 and 74 (30 and 52 respectively in this structure).

Details

Redox score ?
87
PDB code
1mkn
Structure name
n-terminal half of midkine
Structure deposition date
1999-03-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21741
Residue number A
52
Residue number B
74
Peptide name
Midkine

Ligandability

Cysteine 52 of Midkine

Cysteine 74 of Midkine

A redox-regulated disulphide may form within Midkine between cysteines 45 and 70 (23 and 48 respectively in this structure).

Details

Redox score ?
85
PDB code
1mkn
Structure name
n-terminal half of midkine
Structure deposition date
1999-03-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21741
Residue number A
45
Residue number B
70
Peptide name
Midkine

Ligandability

Cysteine 45 of Midkine

Cysteine 70 of Midkine

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