ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Zona pellucida sperm-binding protein 3

Intramolecular
Cysteine 78 and cysteine 98
Cysteine 46 and cysteine 139
A redox-regulated disulphide may form within Zona pellucida sperm-binding protein 3 between cysteines 78 and 98 (408 and 428 respectively in this structure).

Details

Redox score ?
88
PDB code
3d4g
Structure name
zp-n domain of mammalian sperm receptor zp3 (crystal form ii)
Structure deposition date
2008-05-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10761
Residue number A
78
Residue number B
98
Peptide name
Zona pellucida sperm-binding protein 3

Ligandability

Cysteine 78 of Zona pellucida sperm-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 98 of Zona pellucida sperm-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zona pellucida sperm-binding protein 3 between cysteines 46 and 139 (376 and 469 respectively in this structure).

Details

Redox score ?
81
PDB code
3d4g
Structure name
zp-n domain of mammalian sperm receptor zp3 (crystal form ii)
Structure deposition date
2008-05-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10761
Residue number A
46
Residue number B
139
Peptide name
Zona pellucida sperm-binding protein 3

Ligandability

Cysteine 46 of Zona pellucida sperm-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 139 of Zona pellucida sperm-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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