ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Macrophage scavenger receptor types I and II

Intramolecular
Cysteine 419 and cysteine 429
Cysteine 375 and cysteine 439
Cysteine 388 and cysteine 449
A redox-regulated disulphide may form within Macrophage scavenger receptor types I and II between cysteines 419 and 429 (72 and 82 respectively in this structure).

Details

Redox score ?
90
PDB code
7dpx
Structure name
crystal structure of the srcr domain of human scara1/cd204
Structure deposition date
2020-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21757
Residue number A
419
Residue number B
429
Peptide name
Macrophage scavenger receptor types I and II

Ligandability

Cysteine 419 of Macrophage scavenger receptor types I and II

Cysteine 429 of Macrophage scavenger receptor types I and II

A redox-regulated disulphide may form within Macrophage scavenger receptor types I and II between cysteines 375 and 439 (28 and 92 respectively in this structure).

Details

Redox score ?
85
PDB code
7dpx
Structure name
crystal structure of the srcr domain of human scara1/cd204
Structure deposition date
2020-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21757
Residue number A
375
Residue number B
439
Peptide name
Macrophage scavenger receptor types I and II

Ligandability

Cysteine 375 of Macrophage scavenger receptor types I and II

Cysteine 439 of Macrophage scavenger receptor types I and II

A redox-regulated disulphide may form within Macrophage scavenger receptor types I and II between cysteines 388 and 449 (41 and 102 respectively in this structure).

Details

Redox score ?
84
PDB code
7dpx
Structure name
crystal structure of the srcr domain of human scara1/cd204
Structure deposition date
2020-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21757
Residue number A
388
Residue number B
449
Peptide name
Macrophage scavenger receptor types I and II

Ligandability

Cysteine 388 of Macrophage scavenger receptor types I and II

Cysteine 449 of Macrophage scavenger receptor types I and II

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