a tool for identifying drug-targetable redox-active disulphides

Fibroblast growth factor 7

Intramolecular

Cysteine 133 and cysteine 137

A redox-regulated disulphide may form within Fibroblast growth factor 7 between cysteines 133 and 137 (79 and 83 respectively in this structure).

Details

Redox score ?

77

PDB code

Structure name

the crystal structure of fibroblast growth factor 7 (keratinocyte growth factor)

Structure deposition date

1999-06-07

Thiol separation (Å)

4

Half-sphere exposure sum ?

56

Minimum pK_a ?

9

% buried

17

Peptide accession

Residue number A

133

Residue number B

137

Peptide name

Fibroblast growth factor 7

Ligandability

Cysteine 133 of Fibroblast growth factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 137 of Fibroblast growth factor 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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