ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Fibroblast growth factor receptor 2

Intermolecular
Cysteine 491 and cysteine 491
Intramolecular
Cysteine 62 and cysteine 107
Cysteine 278 and cysteine 342
Cysteine 179 and cysteine 231
A redox-regulated disulphide may form between two units of Fibroblast growth factor receptor 2 at cysteines 491 and 491.

Details

Redox score ?
81
PDB code
2psq
Structure name
crystal structure of unphosphorylated unactivated wild type fgf receptor 2 (fgfr2) kinase domain
Structure deposition date
2007-05-07
Thiol separation (Å)
3
Half-sphere exposure sum ?
40
Minimum pKa ?
9
% buried
18
Peptide A name
Fibroblast growth factor receptor 2
Peptide B name
Fibroblast growth factor receptor 2
Peptide A accession
P21802
Peptide B accession
P21802
Peptide A residue number
491
Peptide B residue number
491

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fibroblast growth factor receptor 2 between cysteines 62 and 107.

Details

Redox score ?
85
PDB code
4hwu
Structure name
crystal structure of the ig-c2 type 1 domain from mouse fibroblast growth factor receptor 2 (fgfr2) [nysgrc-005912]
Structure deposition date
2012-11-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21803
Residue number A
62
Residue number B
107
Peptide name
Fibroblast growth factor receptor 2

Ligandability

Cysteine 62 of Fibroblast growth factor receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of Fibroblast growth factor receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fibroblast growth factor receptor 2 between cysteines 278 and 342.

Details

Redox score ?
82
PDB code
1e0o
Structure name
crystal structure of a ternary fgf1-fgfr2-heparin complex
Structure deposition date
2000-04-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21802
Residue number A
278
Residue number B
342
Peptide name
Fibroblast growth factor receptor 2

Ligandability

Cysteine 278 of Fibroblast growth factor receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 342 of Fibroblast growth factor receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fibroblast growth factor receptor 2 between cysteines 179 and 231.

Details

Redox score ?
79
PDB code
3euu
Structure name
crystal structure of the fgfr2 d2 domain
Structure deposition date
2008-10-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21802
Residue number A
179
Residue number B
231
Peptide name
Fibroblast growth factor receptor 2

Ligandability

Cysteine 179 of Fibroblast growth factor receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 231 of Fibroblast growth factor receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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