ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Ryanodine receptor 1

Intramolecular
Cysteine 206 and cysteine 209
Cysteine 230 and cysteine 253
Cysteine 36 and cysteine 65
Cysteine 208 and cysteine 209
Cysteine 230 and cysteine 393
Cysteine 24 and cysteine 65
Cysteine 24 and cysteine 36
Cysteine 746 and cysteine 747
Cysteine 3067 and cysteine 47
Cysteine 206 and cysteine 208
More...
Cysteine 65 and cysteine 66
Cysteine 66 and cysteine 206
Cysteine 253 and cysteine 393
Cysteine 36 and cysteine 66
Cysteine 120 and cysteine 146
Cysteine 1151 and cysteine 1192
Cysteine 47 and cysteine 65
A redox-regulated disulphide may form within Ryanodine receptor 1 between cysteines 206 and 209.

Details

Redox score ?
78
PDB code
4i2s
Structure name
crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant i404m
Structure deposition date
2012-11-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
6
% buried
62
Peptide accession
P11716
Residue number A
206
Residue number B
209
Peptide name
Ryanodine receptor 1

Ligandability

Cysteine 206 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 209 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ryanodine receptor 1 between cysteines 230 and 253.

Details

Redox score ?
70
PDB code
4i0y
Structure name
crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant c36r
Structure deposition date
2012-11-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
9
% buried
50
Peptide accession
P11716
Residue number A
230
Residue number B
253
Peptide name
Ryanodine receptor 1

Ligandability

Cysteine 230 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 253 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ryanodine receptor 1 between cysteines 36 and 65.

Details

Redox score ?
67
PDB code
3ila
Structure name
crystal structure of rabbit ryanodine receptor 1 n-terminal domain (9- 205)
Structure deposition date
2009-08-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
10
% buried
44
Peptide accession
P11716
Residue number A
36
Residue number B
65
Peptide name
Ryanodine receptor 1

Ligandability

Cysteine 36 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 65 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ryanodine receptor 1 between cysteines 208 and 209. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
4i6i
Structure name
crystal structure of rabbit ryanodine receptor 1 (residues 1-559) disease mutant r45c
Structure deposition date
2012-11-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
14
Peptide accession
P11716
Residue number A
208
Residue number B
209
Peptide name
Ryanodine receptor 1

Ligandability

Cysteine 208 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 209 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ryanodine receptor 1 between cysteines 230 and 393. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
4uwa
Structure name
structure of the ryanodine receptor at resolution of 6
Structure deposition date
2014-08-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
7
% buried
80
Peptide accession
P11716
Residue number A
230
Residue number B
393
Peptide name
Ryanodine receptor 1

Ligandability

Cysteine 230 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 393 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ryanodine receptor 1 between cysteines 24 and 65. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3ila
Structure name
crystal structure of rabbit ryanodine receptor 1 n-terminal domain (9- 205)
Structure deposition date
2009-08-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
44
Minimum pKa ?
10
% buried
0
Peptide accession
P11716
Residue number A
24
Residue number B
65
Peptide name
Ryanodine receptor 1

Ligandability

Cysteine 24 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 65 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ryanodine receptor 1 between cysteines 24 and 36. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
3ila
Structure name
crystal structure of rabbit ryanodine receptor 1 n-terminal domain (9- 205)
Structure deposition date
2009-08-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
9
% buried
39
Peptide accession
P11716
Residue number A
24
Residue number B
36
Peptide name
Ryanodine receptor 1

Ligandability

Cysteine 24 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 36 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ryanodine receptor 1 between cysteines 746 and 747. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
4uwe
Structure name
structure of the ryanodine receptor at resolution of 8
Structure deposition date
2014-08-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
10
% buried
68
Peptide accession
P11716
Residue number A
746
Residue number B
747
Peptide name
Ryanodine receptor 1

Ligandability

Cysteine 746 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 747 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ryanodine receptor 1 between cysteines 3067 and 47 (45 and 47 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
4i6i
Structure name
crystal structure of rabbit ryanodine receptor 1 (residues 1-559) disease mutant r45c
Structure deposition date
2012-11-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
63
Peptide accession
P11716
Residue number A
3067
Residue number B
47
Peptide name
Ryanodine receptor 1

Ligandability

Cysteine 3067 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 47 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ryanodine receptor 1 between cysteines 206 and 208. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2xoa
Structure name
crystal structure of the n-terminal three domains of the skeletal muscle ryanodine receptor (ryr1)
Structure deposition date
2010-08-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
42
Peptide accession
P11716
Residue number A
206
Residue number B
208
Peptide name
Ryanodine receptor 1

Ligandability

Cysteine 206 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ryanodine receptor 1 between cysteines 65 and 66. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
3ila
Structure name
crystal structure of rabbit ryanodine receptor 1 n-terminal domain (9- 205)
Structure deposition date
2009-08-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
22
Peptide accession
P11716
Residue number A
65
Residue number B
66
Peptide name
Ryanodine receptor 1

Ligandability

Cysteine 65 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 66 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ryanodine receptor 1 between cysteines 66 and 206. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
4i7i
Structure name
crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant l14r
Structure deposition date
2012-11-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
10
% buried
86
Peptide accession
P11716
Residue number A
66
Residue number B
206
Peptide name
Ryanodine receptor 1

Ligandability

Cysteine 66 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 206 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ryanodine receptor 1 between cysteines 253 and 393. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
4uwa
Structure name
structure of the ryanodine receptor at resolution of 6
Structure deposition date
2014-08-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
11
% buried
58
Peptide accession
P11716
Residue number A
253
Residue number B
393
Peptide name
Ryanodine receptor 1

Ligandability

Cysteine 253 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 393 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ryanodine receptor 1 between cysteines 36 and 66. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
4i2s
Structure name
crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant i404m
Structure deposition date
2012-11-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
96
Peptide accession
P11716
Residue number A
36
Residue number B
66
Peptide name
Ryanodine receptor 1

Ligandability

Cysteine 36 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 66 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ryanodine receptor 1 between cysteines 120 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
3ila
Structure name
crystal structure of rabbit ryanodine receptor 1 n-terminal domain (9- 205)
Structure deposition date
2009-08-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
9
% buried
54
Peptide accession
P11716
Residue number A
120
Residue number B
146
Peptide name
Ryanodine receptor 1

Ligandability

Cysteine 120 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 146 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ryanodine receptor 1 between cysteines 1151 and 1192. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
4p9j
Structure name
crystal structure of rabbit ryanodine receptor 1 spry2 domain (1070- 1246)
Structure deposition date
2014-04-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
96
Minimum pKa ?
12
% buried
90
Peptide accession
P11716
Residue number A
1151
Residue number B
1192
Peptide name
Ryanodine receptor 1

Ligandability

Cysteine 1151 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1192 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ryanodine receptor 1 between cysteines 47 and 65. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
4i0y
Structure name
crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant c36r
Structure deposition date
2012-11-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
98
Peptide accession
P11716
Residue number A
47
Residue number B
65
Peptide name
Ryanodine receptor 1

Ligandability

Cysteine 47 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 65 of Ryanodine receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: