ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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B-cell differentiation antigen CD72

Intramolecular
Cysteine 315 and cysteine 332
Cysteine 232 and cysteine 243
Cysteine 260 and cysteine 340
A redox-regulated disulphide may form within B-cell differentiation antigen CD72 between cysteines 315 and 332.

Details

Redox score ?
87
PDB code
5b1r
Structure name
crystal structure of mouse cd72a ctld
Structure deposition date
2015-12-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21855
Residue number A
315
Residue number B
332
Peptide name
B-cell differentiation antigen CD72

Ligandability

Cysteine 315 of B-cell differentiation antigen CD72

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 332 of B-cell differentiation antigen CD72

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within B-cell differentiation antigen CD72 between cysteines 232 and 243.

Details

Redox score ?
84
PDB code
5b1r
Structure name
crystal structure of mouse cd72a ctld
Structure deposition date
2015-12-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21855
Residue number A
232
Residue number B
243
Peptide name
B-cell differentiation antigen CD72

Ligandability

Cysteine 232 of B-cell differentiation antigen CD72

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 243 of B-cell differentiation antigen CD72

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within B-cell differentiation antigen CD72 between cysteines 260 and 340.

Details

Redox score ?
84
PDB code
5b1r
Structure name
crystal structure of mouse cd72a ctld
Structure deposition date
2015-12-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21855
Residue number A
260
Residue number B
340
Peptide name
B-cell differentiation antigen CD72

Ligandability

Cysteine 260 of B-cell differentiation antigen CD72

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 340 of B-cell differentiation antigen CD72

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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