Receptor tyrosine-protein kinase erbB-3
Intramolecular
Cysteine 613 and cysteine 190
Cysteine 613 and cysteine 226
Cysteine 305 and cysteine 320
Cysteine 617 and cysteine 629
Cysteine 323 and cysteine 327
Cysteine 589 and cysteine 610
Cysteine 556 and cysteine 573
Cysteine 290 and cysteine 301
Cysteine 613 and cysteine 621
Cysteine 520 and cysteine 529
More...Cysteine 533 and cysteine 549
Cysteine 259 and cysteine 286
Cysteine 156 and cysteine 183
Cysteine 210 and cysteine 218
Cysteine 576 and cysteine 585
Cysteine 231 and cysteine 243
Cysteine 214 and cysteine 226
Cysteine 552 and cysteine 565
Cysteine 186 and cysteine 194
Cysteine 246 and cysteine 255
Cysteine 504 and cysteine 517
Cysteine 500 and cysteine 509
Cysteine 290 and cysteine 56
Cysteine 331 and cysteine 354
Cysteine 29 and cysteine 56
Cysteine 463 and cysteine 493
Cysteine 227 and cysteine 235
Cysteine 210 and cysteine 214
Cysteine 186 and cysteine 190
Cysteine 573 and cysteine 585
Cysteine 517 and cysteine 529
Cysteine 243 and cysteine 255
Cysteine 231 and cysteine 235
Cysteine 500 and cysteine 504
Cysteine 231 and cysteine 255
Cysteine 504 and cysteine 509
Cysteine 565 and cysteine 573
Cysteine 613 and cysteine 617
Cysteine 190 and cysteine 194
Cysteine 235 and cysteine 243
5cus D 594 D 602
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 613 and 190 (594 and 602 respectively in this structure).
Details
Redox score ?
93
PDB code
5cus
Structure name
crystal structure of serbb3-fab3379 complex
Structure deposition date
2015-07-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
613
Residue number B
190
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 613 of Receptor tyrosine-protein kinase erbB-3
Cysteine 190 of Receptor tyrosine-protein kinase erbB-3
5cus D 195 D 207
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 613 and 226 (195 and 207 respectively in this structure).
Details
Redox score ?
89
PDB code
5cus
Structure name
crystal structure of serbb3-fab3379 complex
Structure deposition date
2015-07-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
613
Residue number B
226
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 613 of Receptor tyrosine-protein kinase erbB-3
Cysteine 226 of Receptor tyrosine-protein kinase erbB-3
4leo C 286 C 301
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 305 and 320 (286 and 301 respectively in this structure).
Details
Redox score ?
89
PDB code
4leo
Structure name
crystal structure of anti-her3 fab rg7116 in complex with the extracellular domains of human her3 (erbb3)
Structure deposition date
2013-06-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
305
Residue number B
320
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 305 of Receptor tyrosine-protein kinase erbB-3
Cysteine 320 of Receptor tyrosine-protein kinase erbB-3
4p59 A 617 A 629
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 617 and 629.
Details
Redox score ?
88
PDB code
4p59
Structure name
her3 extracellular domain in complex with fab fragment of mor09825
Structure deposition date
2014-03-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
617
Residue number B
629
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 617 of Receptor tyrosine-protein kinase erbB-3
Cysteine 629 of Receptor tyrosine-protein kinase erbB-3
4leo C 304 C 308
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 323 and 327 (304 and 308 respectively in this structure).
Details
Redox score ?
87
PDB code
4leo
Structure name
crystal structure of anti-her3 fab rg7116 in complex with the extracellular domains of human her3 (erbb3)
Structure deposition date
2013-06-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
323
Residue number B
327
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 323 of Receptor tyrosine-protein kinase erbB-3
Cysteine 327 of Receptor tyrosine-protein kinase erbB-3
4leo C 570 C 591
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 589 and 610 (570 and 591 respectively in this structure).
Details
Redox score ?
86
PDB code
4leo
Structure name
crystal structure of anti-her3 fab rg7116 in complex with the extracellular domains of human her3 (erbb3)
Structure deposition date
2013-06-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
589
Residue number B
610
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 589 of Receptor tyrosine-protein kinase erbB-3
Cysteine 610 of Receptor tyrosine-protein kinase erbB-3
4p59 A 556 A 573
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 556 and 573.
Details
Redox score ?
86
PDB code
4p59
Structure name
her3 extracellular domain in complex with fab fragment of mor09825
Structure deposition date
2014-03-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
556
Residue number B
573
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 556 of Receptor tyrosine-protein kinase erbB-3
Cysteine 573 of Receptor tyrosine-protein kinase erbB-3
6kbi B 271 B 282
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 290 and 301 (271 and 282 respectively in this structure).
Details
Redox score ?
86
PDB code
6kbi
Structure name
crystal structure of erbb3 n418q mutant
Structure deposition date
2019-06-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
290
Residue number B
301
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 290 of Receptor tyrosine-protein kinase erbB-3
Cysteine 301 of Receptor tyrosine-protein kinase erbB-3
7bhf D 594 D 602
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 613 and 621 (594 and 602 respectively in this structure).
Details
Redox score ?
86
PDB code
7bhf
Structure name
darpin_d5/her3 domain 4 complex, orthorhombic crystals
Structure deposition date
2021-01-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
613
Residue number B
621
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 613 of Receptor tyrosine-protein kinase erbB-3
Cysteine 621 of Receptor tyrosine-protein kinase erbB-3
7bhe D 501 D 510
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 520 and 529 (501 and 510 respectively in this structure).
Details
Redox score ?
86
PDB code
7bhe
Structure name
darpin_d5/her3 domain 4 complex, monoclinic crystals
Structure deposition date
2021-01-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
520
Residue number B
529
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 520 of Receptor tyrosine-protein kinase erbB-3
Cysteine 529 of Receptor tyrosine-protein kinase erbB-3
5o7p C 533 C 549
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 533 and 549.
Details
Redox score ?
85
PDB code
5o7p
Structure name
her3 in complex with fab mf3178
Structure deposition date
2017-06-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
533
Residue number B
549
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 533 of Receptor tyrosine-protein kinase erbB-3
Cysteine 549 of Receptor tyrosine-protein kinase erbB-3
5cus C 240 C 267
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 259 and 286 (240 and 267 respectively in this structure).
Details
Redox score ?
85
PDB code
5cus
Structure name
crystal structure of serbb3-fab3379 complex
Structure deposition date
2015-07-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
259
Residue number B
286
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 259 of Receptor tyrosine-protein kinase erbB-3
Cysteine 286 of Receptor tyrosine-protein kinase erbB-3
5cus B 137 B 164
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 156 and 183 (137 and 164 respectively in this structure).
Details
Redox score ?
85
PDB code
5cus
Structure name
crystal structure of serbb3-fab3379 complex
Structure deposition date
2015-07-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
156
Residue number B
183
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 156 of Receptor tyrosine-protein kinase erbB-3
Cysteine 183 of Receptor tyrosine-protein kinase erbB-3
5cus A 191 A 199
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 210 and 218 (191 and 199 respectively in this structure).
Details
Redox score ?
85
PDB code
5cus
Structure name
crystal structure of serbb3-fab3379 complex
Structure deposition date
2015-07-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
210
Residue number B
218
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 210 of Receptor tyrosine-protein kinase erbB-3
Cysteine 218 of Receptor tyrosine-protein kinase erbB-3
6kbi B 557 B 566
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 576 and 585 (557 and 566 respectively in this structure).
Details
Redox score ?
85
PDB code
6kbi
Structure name
crystal structure of erbb3 n418q mutant
Structure deposition date
2019-06-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
576
Residue number B
585
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 576 of Receptor tyrosine-protein kinase erbB-3
Cysteine 585 of Receptor tyrosine-protein kinase erbB-3
6kbi A 212 A 224
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 231 and 243 (212 and 224 respectively in this structure).
Details
Redox score ?
85
PDB code
6kbi
Structure name
crystal structure of erbb3 n418q mutant
Structure deposition date
2019-06-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
231
Residue number B
243
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 231 of Receptor tyrosine-protein kinase erbB-3
Cysteine 243 of Receptor tyrosine-protein kinase erbB-3
5o7p C 214 C 226
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 214 and 226.
Details
Redox score ?
84
PDB code
5o7p
Structure name
her3 in complex with fab mf3178
Structure deposition date
2017-06-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
214
Residue number B
226
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 214 of Receptor tyrosine-protein kinase erbB-3
Cysteine 226 of Receptor tyrosine-protein kinase erbB-3
7bhe B 533 B 546
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 552 and 565 (533 and 546 respectively in this structure).
Details
Redox score ?
84
PDB code
7bhe
Structure name
darpin_d5/her3 domain 4 complex, monoclinic crystals
Structure deposition date
2021-01-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
552
Residue number B
565
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 552 of Receptor tyrosine-protein kinase erbB-3
Cysteine 565 of Receptor tyrosine-protein kinase erbB-3
6kbi A 167 A 175
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 186 and 194 (167 and 175 respectively in this structure).
Details
Redox score ?
83
PDB code
6kbi
Structure name
crystal structure of erbb3 n418q mutant
Structure deposition date
2019-06-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
186
Residue number B
194
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 186 of Receptor tyrosine-protein kinase erbB-3
Cysteine 194 of Receptor tyrosine-protein kinase erbB-3
4leo C 227 C 236
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 246 and 255 (227 and 236 respectively in this structure).
Details
Redox score ?
83
PDB code
4leo
Structure name
crystal structure of anti-her3 fab rg7116 in complex with the extracellular domains of human her3 (erbb3)
Structure deposition date
2013-06-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
246
Residue number B
255
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 246 of Receptor tyrosine-protein kinase erbB-3
Cysteine 255 of Receptor tyrosine-protein kinase erbB-3
5o7p C 504 C 517
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 504 and 517.
Details
Redox score ?
83
PDB code
5o7p
Structure name
her3 in complex with fab mf3178
Structure deposition date
2017-06-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
504
Residue number B
517
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 504 of Receptor tyrosine-protein kinase erbB-3
Cysteine 517 of Receptor tyrosine-protein kinase erbB-3
4p59 A 500 A 509
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 500 and 509.
Details
Redox score ?
83
PDB code
4p59
Structure name
her3 extracellular domain in complex with fab fragment of mor09825
Structure deposition date
2014-03-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
500
Residue number B
509
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 500 of Receptor tyrosine-protein kinase erbB-3
Cysteine 509 of Receptor tyrosine-protein kinase erbB-3
1m6b A 10 A 37
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 290 and 56 (10 and 37 respectively in this structure).
Details
Redox score ?
83
PDB code
1m6b
Structure name
structure of the her3 (erbb3) extracellular domain
Structure deposition date
2002-07-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
290
Residue number B
56
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 290 of Receptor tyrosine-protein kinase erbB-3
Cysteine 56 of Receptor tyrosine-protein kinase erbB-3
4leo C 312 C 335
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 331 and 354 (312 and 335 respectively in this structure).
Details
Redox score ?
83
PDB code
4leo
Structure name
crystal structure of anti-her3 fab rg7116 in complex with the extracellular domains of human her3 (erbb3)
Structure deposition date
2013-06-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
331
Residue number B
354
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 331 of Receptor tyrosine-protein kinase erbB-3
Cysteine 354 of Receptor tyrosine-protein kinase erbB-3
3p11 A 10 A 37
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 29 and 56 (10 and 37 respectively in this structure).
Details
Redox score ?
83
PDB code
3p11
Structure name
anti-egfr/her3 fab dl11 in complex with domains i-iii of the her3 extracellular region
Structure deposition date
2010-09-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
29
Residue number B
56
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 29 of Receptor tyrosine-protein kinase erbB-3
Cysteine 56 of Receptor tyrosine-protein kinase erbB-3
5o7p C 463 C 493
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 463 and 493.
Details
Redox score ?
82
PDB code
5o7p
Structure name
her3 in complex with fab mf3178
Structure deposition date
2017-06-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
463
Residue number B
493
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 463 of Receptor tyrosine-protein kinase erbB-3
Cysteine 493 of Receptor tyrosine-protein kinase erbB-3
6kbi A 208 A 216
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 227 and 235 (208 and 216 respectively in this structure).
Details
Redox score ?
81
PDB code
6kbi
Structure name
crystal structure of erbb3 n418q mutant
Structure deposition date
2019-06-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
227
Residue number B
235
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 227 of Receptor tyrosine-protein kinase erbB-3
Cysteine 235 of Receptor tyrosine-protein kinase erbB-3
3p11 A 191 A 195
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 210 and 214 (191 and 195 respectively in this structure).
Details
Redox score ?
80
PDB code
3p11
Structure name
anti-egfr/her3 fab dl11 in complex with domains i-iii of the her3 extracellular region
Structure deposition date
2010-09-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
210
Residue number B
214
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 210 of Receptor tyrosine-protein kinase erbB-3
Cysteine 214 of Receptor tyrosine-protein kinase erbB-3
5o7p C 186 C 190
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 186 and 190.
Details
Redox score ?
75
PDB code
5o7p
Structure name
her3 in complex with fab mf3178
Structure deposition date
2017-06-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
186
Residue number B
190
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 186 of Receptor tyrosine-protein kinase erbB-3
Cysteine 190 of Receptor tyrosine-protein kinase erbB-3
7bhf B 554 B 566
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 573 and 585 (554 and 566 respectively in this structure).
Details
Redox score ?
75
PDB code
7bhf
Structure name
darpin_d5/her3 domain 4 complex, orthorhombic crystals
Structure deposition date
2021-01-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
573
Residue number B
585
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 573 of Receptor tyrosine-protein kinase erbB-3
Cysteine 585 of Receptor tyrosine-protein kinase erbB-3
5cus D 498 D 510
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 517 and 529 (498 and 510 respectively in this structure).
Details
Redox score ?
75
PDB code
5cus
Structure name
crystal structure of serbb3-fab3379 complex
Structure deposition date
2015-07-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
517
Residue number B
529
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 517 of Receptor tyrosine-protein kinase erbB-3
Cysteine 529 of Receptor tyrosine-protein kinase erbB-3
6kbi B 224 B 236
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 243 and 255 (224 and 236 respectively in this structure).
Details
Redox score ?
75
PDB code
6kbi
Structure name
crystal structure of erbb3 n418q mutant
Structure deposition date
2019-06-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
243
Residue number B
255
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 243 of Receptor tyrosine-protein kinase erbB-3
Cysteine 255 of Receptor tyrosine-protein kinase erbB-3
4p59 A 231 A 235
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 231 and 235.
Details
Redox score ?
75
PDB code
4p59
Structure name
her3 extracellular domain in complex with fab fragment of mor09825
Structure deposition date
2014-03-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
231
Residue number B
235
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 231 of Receptor tyrosine-protein kinase erbB-3
Cysteine 235 of Receptor tyrosine-protein kinase erbB-3
5cus C 481 C 485
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 500 and 504 (481 and 485 respectively in this structure).
Details
Redox score ?
73
PDB code
5cus
Structure name
crystal structure of serbb3-fab3379 complex
Structure deposition date
2015-07-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
500
Residue number B
504
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 500 of Receptor tyrosine-protein kinase erbB-3
Cysteine 504 of Receptor tyrosine-protein kinase erbB-3
5cus C 212 C 236
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 231 and 255 (212 and 236 respectively in this structure).
Details
Redox score ?
73
PDB code
5cus
Structure name
crystal structure of serbb3-fab3379 complex
Structure deposition date
2015-07-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
231
Residue number B
255
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 231 of Receptor tyrosine-protein kinase erbB-3
Cysteine 255 of Receptor tyrosine-protein kinase erbB-3
7bhf B 485 B 490
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 504 and 509 (485 and 490 respectively in this structure).
Details
Redox score ?
72
PDB code
7bhf
Structure name
darpin_d5/her3 domain 4 complex, orthorhombic crystals
Structure deposition date
2021-01-11
Thiol separation (Å)
5
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
504
Residue number B
509
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 504 of Receptor tyrosine-protein kinase erbB-3
Cysteine 509 of Receptor tyrosine-protein kinase erbB-3
5cus A 546 A 554
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 565 and 573 (546 and 554 respectively in this structure).
Details
Redox score ?
72
PDB code
5cus
Structure name
crystal structure of serbb3-fab3379 complex
Structure deposition date
2015-07-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
565
Residue number B
573
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 565 of Receptor tyrosine-protein kinase erbB-3
Cysteine 573 of Receptor tyrosine-protein kinase erbB-3
7bhf D 594 D 598
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 613 and 617 (594 and 598 respectively in this structure).
Details
Redox score ?
71
PDB code
7bhf
Structure name
darpin_d5/her3 domain 4 complex, orthorhombic crystals
Structure deposition date
2021-01-11
Thiol separation (Å)
5
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
613
Residue number B
617
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 613 of Receptor tyrosine-protein kinase erbB-3
Cysteine 617 of Receptor tyrosine-protein kinase erbB-3
5cus D 171 D 175
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 190 and 194 (171 and 175 respectively in this structure).
Details
Redox score ?
71
PDB code
5cus
Structure name
crystal structure of serbb3-fab3379 complex
Structure deposition date
2015-07-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
11
% buried
nan
Peptide accession
P21860
Residue number A
190
Residue number B
194
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 190 of Receptor tyrosine-protein kinase erbB-3
Cysteine 194 of Receptor tyrosine-protein kinase erbB-3
5o7p C 235 C 243
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-3 between cysteines 235 and 243.
Details
Redox score ?
71
PDB code
5o7p
Structure name
her3 in complex with fab mf3178
Structure deposition date
2017-06-09
Thiol separation (Å)
5
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P21860
Residue number A
235
Residue number B
243
Peptide name
Receptor tyrosine-protein kinase erbB-3
Ligandability
Cysteine 235 of Receptor tyrosine-protein kinase erbB-3
Cysteine 243 of Receptor tyrosine-protein kinase erbB-3
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