ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Potassium voltage-gated channel subfamily A member 3

Intramolecular
Cysteine 101 and cysteine 123
Cysteine 101 and cysteine 102
Cysteine 102 and cysteine 123
A redox-regulated disulphide may form within Potassium voltage-gated channel subfamily A member 3 between cysteines 101 and 123.

Details

Redox score ?
87
PDB code
7wf4
Structure name
composite map of human kv1
Structure deposition date
2021-12-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22001
Residue number A
101
Residue number B
123
Peptide name
Potassium voltage-gated channel subfamily A member 3

Ligandability

Cysteine 101 of Potassium voltage-gated channel subfamily A member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 123 of Potassium voltage-gated channel subfamily A member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Potassium voltage-gated channel subfamily A member 3 between cysteines 101 and 102. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
7wf3
Structure name
composite map of human kv1
Structure deposition date
2021-12-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
37
Minimum pKa ?
9
% buried
nan
Peptide accession
P22001
Residue number A
101
Residue number B
102
Peptide name
Potassium voltage-gated channel subfamily A member 3

Ligandability

Cysteine 101 of Potassium voltage-gated channel subfamily A member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 102 of Potassium voltage-gated channel subfamily A member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Potassium voltage-gated channel subfamily A member 3 between cysteines 102 and 123. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
7wf4
Structure name
composite map of human kv1
Structure deposition date
2021-12-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
nan
Peptide accession
P22001
Residue number A
102
Residue number B
123
Peptide name
Potassium voltage-gated channel subfamily A member 3

Ligandability

Cysteine 102 of Potassium voltage-gated channel subfamily A member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 123 of Potassium voltage-gated channel subfamily A member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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