ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Bone morphogenetic protein 6

Intermolecular
Cysteine 477 and cysteine 477
Cysteine 477 and cysteine 478
Cysteine 477 and cysteine 441
Cysteine 477 and cysteine 412
Cysteine 477 and cysteine 510
Intramolecular
Cysteine 441 and cysteine 510
Cysteine 412 and cysteine 478
Cysteine 445 and cysteine 512
Cysteine 412 and cysteine 445
Cysteine 412 and cysteine 512
More...
Cysteine 412 and cysteine 510
Cysteine 478 and cysteine 510
Cysteine 445 and cysteine 478
Cysteine 441 and cysteine 478
Cysteine 412 and cysteine 441
Cysteine 478 and cysteine 512
Cysteine 445 and cysteine 477
Cysteine 441 and cysteine 445
Cysteine 445 and cysteine 510
Cysteine 510 and cysteine 512
Cysteine 477 and cysteine 512
Cysteine 441 and cysteine 512
A redox-regulated disulphide may form between two units of Bone morphogenetic protein 6 at cysteines 477 and 477 (96 and 96 respectively in this structure).

Details

Redox score ?
77
PDB code
2r53
Structure name
crystal structure analysis of bone morphogenetic protein-6 variant b2 (b2-bmp-6)
Structure deposition date
2007-09-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide A name
Bone morphogenetic protein 6
Peptide B name
Bone morphogenetic protein 6
Peptide A accession
P22004
Peptide B accession
P22004
Peptide A residue number
477
Peptide B residue number
477

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Bone morphogenetic protein 6 at cysteines 477 and 478 (96 and 97 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
2r52
Structure name
crystal structure analysis of bone morphogenetic protein-6 (bmp-6)
Structure deposition date
2007-09-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide A name
Bone morphogenetic protein 6
Peptide B name
Bone morphogenetic protein 6
Peptide A accession
P22004
Peptide B accession
P22004
Peptide A residue number
477
Peptide B residue number
478

Ligandability

Cysteine 477 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 478 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Bone morphogenetic protein 6 at cysteines 477 and 441 (96 and 60 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2r52
Structure name
crystal structure analysis of bone morphogenetic protein-6 (bmp-6)
Structure deposition date
2007-09-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide A name
Bone morphogenetic protein 6
Peptide B name
Bone morphogenetic protein 6
Peptide A accession
P22004
Peptide B accession
P22004
Peptide A residue number
477
Peptide B residue number
441

Ligandability

Cysteine 477 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 441 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Bone morphogenetic protein 6 at cysteines 477 and 412 (96 and 31 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
2r53
Structure name
crystal structure analysis of bone morphogenetic protein-6 variant b2 (b2-bmp-6)
Structure deposition date
2007-09-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide A name
Bone morphogenetic protein 6
Peptide B name
Bone morphogenetic protein 6
Peptide A accession
P22004
Peptide B accession
P22004
Peptide A residue number
477
Peptide B residue number
412

Ligandability

Cysteine 477 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 412 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Bone morphogenetic protein 6 at cysteines 477 and 510 (103 and 136 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6omo
Structure name
human bmp6 homodimer
Structure deposition date
2019-04-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide A name
Bone morphogenetic protein 6
Peptide B name
Bone morphogenetic protein 6
Peptide A accession
P22004
Peptide B accession
P22004
Peptide A residue number
477
Peptide B residue number
510

Ligandability

Cysteine 477 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 510 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bone morphogenetic protein 6 between cysteines 441 and 510 (60 and 129 respectively in this structure).

Details

Redox score ?
85
PDB code
2qcw
Structure name
crystal structure of bone morphogenetic protein-6 (bmp-6)
Structure deposition date
2007-06-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22004
Residue number A
441
Residue number B
510
Peptide name
Bone morphogenetic protein 6

Ligandability

Cysteine 441 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 510 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bone morphogenetic protein 6 between cysteines 412 and 478 (38 and 104 respectively in this structure).

Details

Redox score ?
85
PDB code
6omo
Structure name
human bmp6 homodimer
Structure deposition date
2019-04-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22004
Residue number A
412
Residue number B
478
Peptide name
Bone morphogenetic protein 6

Ligandability

Cysteine 412 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 478 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bone morphogenetic protein 6 between cysteines 445 and 512 (64 and 131 respectively in this structure).

Details

Redox score ?
82
PDB code
2r53
Structure name
crystal structure analysis of bone morphogenetic protein-6 variant b2 (b2-bmp-6)
Structure deposition date
2007-09-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22004
Residue number A
445
Residue number B
512
Peptide name
Bone morphogenetic protein 6

Ligandability

Cysteine 445 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 512 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bone morphogenetic protein 6 between cysteines 412 and 445 (31 and 64 respectively in this structure).

Details

Redox score ?
75
PDB code
2r52
Structure name
crystal structure analysis of bone morphogenetic protein-6 (bmp-6)
Structure deposition date
2007-09-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22004
Residue number A
412
Residue number B
445
Peptide name
Bone morphogenetic protein 6

Ligandability

Cysteine 412 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 445 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bone morphogenetic protein 6 between cysteines 412 and 512 (31 and 131 respectively in this structure).

Details

Redox score ?
73
PDB code
2r52
Structure name
crystal structure analysis of bone morphogenetic protein-6 (bmp-6)
Structure deposition date
2007-09-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22004
Residue number A
412
Residue number B
512
Peptide name
Bone morphogenetic protein 6

Ligandability

Cysteine 412 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 512 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bone morphogenetic protein 6 between cysteines 412 and 510 (31 and 129 respectively in this structure).

Details

Redox score ?
67
PDB code
2r52
Structure name
crystal structure analysis of bone morphogenetic protein-6 (bmp-6)
Structure deposition date
2007-09-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22004
Residue number A
412
Residue number B
510
Peptide name
Bone morphogenetic protein 6

Ligandability

Cysteine 412 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 510 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bone morphogenetic protein 6 between cysteines 478 and 510 (97 and 129 respectively in this structure).

Details

Redox score ?
67
PDB code
2r52
Structure name
crystal structure analysis of bone morphogenetic protein-6 (bmp-6)
Structure deposition date
2007-09-03
Thiol separation (Å)
5
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22004
Residue number A
478
Residue number B
510
Peptide name
Bone morphogenetic protein 6

Ligandability

Cysteine 478 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 510 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bone morphogenetic protein 6 between cysteines 445 and 478 (64 and 97 respectively in this structure).

Details

Redox score ?
66
PDB code
2qcw
Structure name
crystal structure of bone morphogenetic protein-6 (bmp-6)
Structure deposition date
2007-06-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22004
Residue number A
445
Residue number B
478
Peptide name
Bone morphogenetic protein 6

Ligandability

Cysteine 445 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 478 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bone morphogenetic protein 6 between cysteines 441 and 478 (60 and 97 respectively in this structure).

Details

Redox score ?
66
PDB code
2r53
Structure name
crystal structure analysis of bone morphogenetic protein-6 variant b2 (b2-bmp-6)
Structure deposition date
2007-09-03
Thiol separation (Å)
5
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22004
Residue number A
441
Residue number B
478
Peptide name
Bone morphogenetic protein 6

Ligandability

Cysteine 441 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 478 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bone morphogenetic protein 6 between cysteines 412 and 441 (31 and 60 respectively in this structure).

Details

Redox score ?
64
PDB code
2r52
Structure name
crystal structure analysis of bone morphogenetic protein-6 (bmp-6)
Structure deposition date
2007-09-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22004
Residue number A
412
Residue number B
441
Peptide name
Bone morphogenetic protein 6

Ligandability

Cysteine 412 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 441 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bone morphogenetic protein 6 between cysteines 478 and 512 (104 and 138 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
6omo
Structure name
human bmp6 homodimer
Structure deposition date
2019-04-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22004
Residue number A
478
Residue number B
512
Peptide name
Bone morphogenetic protein 6

Ligandability

Cysteine 478 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 512 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bone morphogenetic protein 6 between cysteines 445 and 477 (64 and 96 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
2r52
Structure name
crystal structure analysis of bone morphogenetic protein-6 (bmp-6)
Structure deposition date
2007-09-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22004
Residue number A
445
Residue number B
477
Peptide name
Bone morphogenetic protein 6

Ligandability

Cysteine 445 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 477 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bone morphogenetic protein 6 between cysteines 441 and 445 (60 and 64 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
2r52
Structure name
crystal structure analysis of bone morphogenetic protein-6 (bmp-6)
Structure deposition date
2007-09-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22004
Residue number A
441
Residue number B
445
Peptide name
Bone morphogenetic protein 6

Ligandability

Cysteine 441 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 445 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bone morphogenetic protein 6 between cysteines 445 and 510 (64 and 129 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2qcw
Structure name
crystal structure of bone morphogenetic protein-6 (bmp-6)
Structure deposition date
2007-06-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22004
Residue number A
445
Residue number B
510
Peptide name
Bone morphogenetic protein 6

Ligandability

Cysteine 445 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 510 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bone morphogenetic protein 6 between cysteines 510 and 512 (129 and 131 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2qcw
Structure name
crystal structure of bone morphogenetic protein-6 (bmp-6)
Structure deposition date
2007-06-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22004
Residue number A
510
Residue number B
512
Peptide name
Bone morphogenetic protein 6

Ligandability

Cysteine 510 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 512 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bone morphogenetic protein 6 between cysteines 477 and 512 (96 and 131 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2r52
Structure name
crystal structure analysis of bone morphogenetic protein-6 (bmp-6)
Structure deposition date
2007-09-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22004
Residue number A
477
Residue number B
512
Peptide name
Bone morphogenetic protein 6

Ligandability

Cysteine 477 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 512 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bone morphogenetic protein 6 between cysteines 441 and 512 (60 and 131 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2qcw
Structure name
crystal structure of bone morphogenetic protein-6 (bmp-6)
Structure deposition date
2007-06-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22004
Residue number A
441
Residue number B
512
Peptide name
Bone morphogenetic protein 6

Ligandability

Cysteine 441 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 512 of Bone morphogenetic protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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