ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin-10

Intermolecular
Cysteine 132 and cysteine 132
Cysteine 80 and cysteine 132
Intramolecular
Cysteine 30 and cysteine 126
Cysteine 80 and cysteine 132
A redox-regulated disulphide may form between two units of Interleukin-10 at cysteines 132 and 132 (114 and 114 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
4x51
Structure name
x-ray structure of mouse interleukin-10 mutant - s1_e8del, c149y
Structure deposition date
2014-12-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-10
Peptide B name
Interleukin-10
Peptide A accession
P18893
Peptide B accession
P18893
Peptide A residue number
132
Peptide B residue number
132

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Interleukin-10 at cysteines 80 and 132 (62 and 114 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
4x51
Structure name
x-ray structure of mouse interleukin-10 mutant - s1_e8del, c149y
Structure deposition date
2014-12-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-10
Peptide B name
Interleukin-10
Peptide A accession
P18893
Peptide B accession
P18893
Peptide A residue number
80
Peptide B residue number
132

Ligandability

Cysteine 80 of Interleukin-10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 132 of Interleukin-10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-10 between cysteines 30 and 126 (12 and 108 respectively in this structure).

Details

Redox score ?
88
PDB code
1j7v
Structure name
human il-10 / il-10r1 complex
Structure deposition date
2001-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22301
Residue number A
30
Residue number B
126
Peptide name
Interleukin-10

Ligandability

Cysteine 30 of Interleukin-10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of Interleukin-10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-10 between cysteines 80 and 132 (62 and 114 respectively in this structure).

Details

Redox score ?
83
PDB code
2h24
Structure name
crystal structure of human il-10
Structure deposition date
2006-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22301
Residue number A
80
Residue number B
132
Peptide name
Interleukin-10

Ligandability

Cysteine 80 of Interleukin-10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 132 of Interleukin-10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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