ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Iduronate 2-sulfatase

Intramolecular
Cysteine 422 and cysteine 432
Cysteine 171 and cysteine 184
A redox-regulated disulphide may form within Iduronate 2-sulfatase between cysteines 422 and 432.

Details

Redox score ?
83
PDB code
6ioz
Structure name
structural insights of idursulfase beta
Structure deposition date
2018-11-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22304
Residue number A
422
Residue number B
432
Peptide name
Iduronate 2-sulfatase

Ligandability

Cysteine 422 of Iduronate 2-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 432 of Iduronate 2-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Iduronate 2-sulfatase between cysteines 171 and 184.

Details

Redox score ?
81
PDB code
5fql
Structure name
insights into hunter syndrome from the structure of iduronate-2- sulfatase
Structure deposition date
2015-12-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22304
Residue number A
171
Residue number B
184
Peptide name
Iduronate 2-sulfatase

Ligandability

Cysteine 171 of Iduronate 2-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 184 of Iduronate 2-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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