ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Fibroblast growth factor receptor 4

Intramolecular
Cysteine 271 and cysteine 333
Cysteine 172 and cysteine 224
A redox-regulated disulphide may form within Fibroblast growth factor receptor 4 between cysteines 271 and 333.

Details

Redox score ?
81
PDB code
7tyd
Structure name
crystal structure of fgfr4 domain 3 in complex with a de novo-designed mini-binder in p21 space group
Structure deposition date
2022-02-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22455
Residue number A
271
Residue number B
333
Peptide name
Fibroblast growth factor receptor 4

Ligandability

Cysteine 271 of Fibroblast growth factor receptor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 333 of Fibroblast growth factor receptor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fibroblast growth factor receptor 4 between cysteines 172 and 224 (179 and 231 respectively in this structure).

Details

Redox score ?
79
PDB code
6j6y
Structure name
fgfr4 d2 - fab complex
Structure deposition date
2019-01-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22455
Residue number A
172
Residue number B
224
Peptide name
Fibroblast growth factor receptor 4

Ligandability

Cysteine 172 of Fibroblast growth factor receptor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 224 of Fibroblast growth factor receptor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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