ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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5-aminolevulinate synthase, erythroid-specific, mitochondrial

Intramolecular
Cysteine 338 and cysteine 344
Cysteine 195 and cysteine 490
A redox-regulated disulphide may form within 5-aminolevulinate synthase, erythroid-specific, mitochondrial between cysteines 338 and 344. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
5qqs
Structure name
pandda analysis group deposition -- crystal structure of human alas2a in complex with z275151340
Structure deposition date
2019-05-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
78
Minimum pKa ?
13
% buried
96
Peptide accession
P22557
Residue number A
338
Residue number B
344
Peptide name
5-aminolevulinate synthase, erythroid-specific, mitochondrial

Ligandability

Cysteine 338 of 5-aminolevulinate synthase, erythroid-specific, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 344 of 5-aminolevulinate synthase, erythroid-specific, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 5-aminolevulinate synthase, erythroid-specific, mitochondrial between cysteines 195 and 490. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6hrh
Structure name
structure of human erythroid-specific 5'-aminolevulinate synthase, alas2
Structure deposition date
2018-09-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
97
Peptide accession
P22557
Residue number A
195
Residue number B
490
Peptide name
5-aminolevulinate synthase, erythroid-specific, mitochondrial

Ligandability

Cysteine 195 of 5-aminolevulinate synthase, erythroid-specific, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 490 of 5-aminolevulinate synthase, erythroid-specific, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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