ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

NADPH:adrenodoxin oxidoreductase, mitochondrial

Intramolecular
Cysteine 177 and cysteine 354
A redox-regulated disulphide may form within NADPH:adrenodoxin oxidoreductase, mitochondrial between cysteines 177 and 354 (145 and 322 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
1e6e
Structure name
adrenodoxin reductase/adrenodoxin complex of mitochondrial p450 systems
Structure deposition date
2000-08-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
56
Peptide accession
P08165
Residue number A
177
Residue number B
354
Peptide name
NADPH:adrenodoxin oxidoreductase, mitochondrial

Ligandability

Cysteine 177 of NADPH:adrenodoxin oxidoreductase, mitochondrial

Cysteine 354 of NADPH:adrenodoxin oxidoreductase, mitochondrial

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