ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Carbonic anhydrase 4

Intramolecular
Cysteine 46 and cysteine 229
Cysteine 24 and cysteine 36
A redox-regulated disulphide may form within Carbonic anhydrase 4 between cysteines 46 and 229 (23 and 203 respectively in this structure).

Details

Redox score ?
88
PDB code
5jn9
Structure name
crystal structure for the complex of human carbonic anhydrase iv and ethoxyzolamide
Structure deposition date
2016-04-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22748
Residue number A
46
Residue number B
229
Peptide name
Carbonic anhydrase 4

Ligandability

Cysteine 46 of Carbonic anhydrase 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 229 of Carbonic anhydrase 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Carbonic anhydrase 4 between cysteines 24 and 36 (7 and 19 respectively in this structure).

Details

Redox score ?
85
PDB code
5ipz
Structure name
crystal structure of human carbonic anhydrase isozyme iv with 5-(2- amino-1,3-thiazol-4-yl)-2-chlorobenzenesulfonamide
Structure deposition date
2016-03-10
Thiol separation (Å)
3
Half-sphere exposure sum ?
50
Minimum pKa ?
8
% buried
11
Peptide accession
P22748
Residue number A
24
Residue number B
36
Peptide name
Carbonic anhydrase 4

Ligandability

Cysteine 24 of Carbonic anhydrase 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 36 of Carbonic anhydrase 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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