ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Granulysin

Intramolecular
Cysteine 96 and cysteine 107
Cysteine 69 and cysteine 132
A redox-regulated disulphide may form within Granulysin between cysteines 96 and 107 (34 and 45 respectively in this structure).

Details

Redox score ?
85
PDB code
1l9l
Structure name
granulysin from human cytolytic t lymphocytes
Structure deposition date
2002-03-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22749
Residue number A
96
Residue number B
107
Peptide name
Granulysin

Ligandability

Cysteine 96 of Granulysin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of Granulysin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulysin between cysteines 69 and 132 (7 and 70 respectively in this structure).

Details

Redox score ?
84
PDB code
1l9l
Structure name
granulysin from human cytolytic t lymphocytes
Structure deposition date
2002-03-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22749
Residue number A
69
Residue number B
132
Peptide name
Granulysin

Ligandability

Cysteine 69 of Granulysin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 132 of Granulysin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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