ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Lutropin-choriogonadotropic hormone receptor

Intermolecular
Cysteine 156 and cysteine 120 of Choriogonadotropin subunit beta 3
Cysteine 131 and cysteine 120 of Choriogonadotropin subunit beta 3
Cysteine 156 and cysteine 113 of Choriogonadotropin subunit beta 3
Cysteine 131 and cysteine 113 of Choriogonadotropin subunit beta 3
Intramolecular
Cysteine 279 and cysteine 343
Cysteine 439 and cysteine 514
Cysteine 280 and cysteine 353
Cysteine 131 and cysteine 156
Cysteine 643 and cysteine 699
Cysteine 279 and cysteine 280
More...
Cysteine 280 and cysteine 343
Cysteine 279 and cysteine 353
Cysteine 343 and cysteine 353
Cysteine 543 and cysteine 545
Cysteine 581 and cysteine 617
A redox-regulated disulphide may form between cysteine 156 of Lutropin-choriogonadotropic hormone receptor and cysteine 120 of Choriogonadotropin subunit beta 3 (156 and 100 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide A name
Lutropin-choriogonadotropic hormone receptor
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P22888
Peptide B accession
P0DN86
Peptide A residue number
156
Peptide B residue number
120

Ligandability

Cysteine 156 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 131 of Lutropin-choriogonadotropic hormone receptor and cysteine 120 of Choriogonadotropin subunit beta 3 (131 and 100 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
93
Minimum pKa ?
nan
% buried
nan
Peptide A name
Lutropin-choriogonadotropic hormone receptor
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P22888
Peptide B accession
P0DN86
Peptide A residue number
131
Peptide B residue number
120

Ligandability

Cysteine 131 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 156 of Lutropin-choriogonadotropic hormone receptor and cysteine 113 of Choriogonadotropin subunit beta 3 (156 and 93 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7fih
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs-org43553 complex
Structure deposition date
2021-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide A name
Lutropin-choriogonadotropic hormone receptor
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P22888
Peptide B accession
P0DN86
Peptide A residue number
156
Peptide B residue number
113

Ligandability

Cysteine 156 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 131 of Lutropin-choriogonadotropic hormone receptor and cysteine 113 of Choriogonadotropin subunit beta 3 (131 and 93 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide A name
Lutropin-choriogonadotropic hormone receptor
Peptide B name
Choriogonadotropin subunit beta 3
Peptide A accession
P22888
Peptide B accession
P0DN86
Peptide A residue number
131
Peptide B residue number
113

Ligandability

Cysteine 131 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Choriogonadotropin subunit beta 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lutropin-choriogonadotropic hormone receptor between cysteines 279 and 343.

Details

Redox score ?
84
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22888
Residue number A
279
Residue number B
343
Peptide name
Lutropin-choriogonadotropic hormone receptor

Ligandability

Cysteine 279 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 343 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lutropin-choriogonadotropic hormone receptor between cysteines 439 and 514.

Details

Redox score ?
84
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22888
Residue number A
439
Residue number B
514
Peptide name
Lutropin-choriogonadotropic hormone receptor

Ligandability

Cysteine 439 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 514 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lutropin-choriogonadotropic hormone receptor between cysteines 280 and 353.

Details

Redox score ?
80
PDB code
7fih
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs-org43553 complex
Structure deposition date
2021-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22888
Residue number A
280
Residue number B
353
Peptide name
Lutropin-choriogonadotropic hormone receptor

Ligandability

Cysteine 280 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 353 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lutropin-choriogonadotropic hormone receptor between cysteines 131 and 156.

Details

Redox score ?
77
PDB code
7fih
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs-org43553 complex
Structure deposition date
2021-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22888
Residue number A
131
Residue number B
156
Peptide name
Lutropin-choriogonadotropic hormone receptor

Ligandability

Cysteine 131 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 156 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lutropin-choriogonadotropic hormone receptor between cysteines 643 and 699 (643 and 644 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
P22888
Residue number A
643
Residue number B
699
Peptide name
Lutropin-choriogonadotropic hormone receptor

Ligandability

Cysteine 643 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 699 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lutropin-choriogonadotropic hormone receptor between cysteines 279 and 280. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22888
Residue number A
279
Residue number B
280
Peptide name
Lutropin-choriogonadotropic hormone receptor

Ligandability

Cysteine 279 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 280 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lutropin-choriogonadotropic hormone receptor between cysteines 280 and 343. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
7fih
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs-org43553 complex
Structure deposition date
2021-07-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22888
Residue number A
280
Residue number B
343
Peptide name
Lutropin-choriogonadotropic hormone receptor

Ligandability

Cysteine 280 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 343 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lutropin-choriogonadotropic hormone receptor between cysteines 279 and 353. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7fih
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs-org43553 complex
Structure deposition date
2021-07-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22888
Residue number A
279
Residue number B
353
Peptide name
Lutropin-choriogonadotropic hormone receptor

Ligandability

Cysteine 279 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 353 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lutropin-choriogonadotropic hormone receptor between cysteines 343 and 353. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7fih
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs-org43553 complex
Structure deposition date
2021-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22888
Residue number A
343
Residue number B
353
Peptide name
Lutropin-choriogonadotropic hormone receptor

Ligandability

Cysteine 343 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 353 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lutropin-choriogonadotropic hormone receptor between cysteines 543 and 545. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7fih
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs-org43553 complex
Structure deposition date
2021-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
26
Peptide accession
P22888
Residue number A
543
Residue number B
545
Peptide name
Lutropin-choriogonadotropic hormone receptor

Ligandability

Cysteine 543 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 545 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lutropin-choriogonadotropic hormone receptor between cysteines 581 and 617. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7fig
Structure name
luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex
Structure deposition date
2021-07-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
89
Peptide accession
P22888
Residue number A
581
Residue number B
617
Peptide name
Lutropin-choriogonadotropic hormone receptor

Ligandability

Cysteine 581 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 617 of Lutropin-choriogonadotropic hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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