ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Vitamin K-dependent protein Z

Intramolecular
Cysteine 96 and cysteine 111
Cysteine 91 and cysteine 102
Cysteine 113 and cysteine 122
Cysteine 152 and cysteine 165
Cysteine 171 and cysteine 273
Cysteine 137 and cysteine 150
Cysteine 327 and cysteine 341
Cysteine 129 and cysteine 141
Cysteine 203 and cysteine 219
Cysteine 173 and cysteine 281
More...
Cysteine 96 and cysteine 102
Cysteine 111 and cysteine 122
Cysteine 137 and cysteine 141
Cysteine 96 and cysteine 122
Cysteine 102 and cysteine 111
Cysteine 111 and cysteine 113
Cysteine 91 and cysteine 96
Cysteine 129 and cysteine 137
Cysteine 96 and cysteine 113
Cysteine 141 and cysteine 150
Cysteine 91 and cysteine 111
Cysteine 150 and cysteine 165
Cysteine 129 and cysteine 150
Cysteine 137 and cysteine 165
Cysteine 150 and cysteine 152
Cysteine 137 and cysteine 152
Cysteine 102 and cysteine 122
Cysteine 171 and cysteine 173
Cysteine 165 and cysteine 173
Cysteine 173 and cysteine 273
Cysteine 165 and cysteine 281
Cysteine 152 and cysteine 281
Cysteine 152 and cysteine 173
A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 96 and 111 (56 and 71 respectively in this structure).

Details

Redox score ?
89
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
96
Residue number B
111
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 96 of Vitamin K-dependent protein Z

Cysteine 111 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 91 and 102 (51 and 62 respectively in this structure).

Details

Redox score ?
88
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
91
Residue number B
102
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 91 of Vitamin K-dependent protein Z

Cysteine 102 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 113 and 122 (73 and 82 respectively in this structure).

Details

Redox score ?
87
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
113
Residue number B
122
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 113 of Vitamin K-dependent protein Z

Cysteine 122 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 152 and 165 (112 and 125 respectively in this structure).

Details

Redox score ?
86
PDB code
3f1s
Structure name
crystal structure of protein z complexed with protein z-dependent inhibitor
Structure deposition date
2008-10-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
152
Residue number B
165
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 152 of Vitamin K-dependent protein Z

Cysteine 165 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 171 and 273 (131 and 233 respectively in this structure).

Details

Redox score ?
86
PDB code
3f1s
Structure name
crystal structure of protein z complexed with protein z-dependent inhibitor
Structure deposition date
2008-10-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
171
Residue number B
273
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 171 of Vitamin K-dependent protein Z

Cysteine 273 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 137 and 150 (97 and 110 respectively in this structure).

Details

Redox score ?
85
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
137
Residue number B
150
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 137 of Vitamin K-dependent protein Z

Cysteine 150 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 327 and 341 (287 and 301 respectively in this structure).

Details

Redox score ?
83
PDB code
3f1s
Structure name
crystal structure of protein z complexed with protein z-dependent inhibitor
Structure deposition date
2008-10-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
327
Residue number B
341
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 327 of Vitamin K-dependent protein Z

Cysteine 341 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 129 and 141 (89 and 101 respectively in this structure).

Details

Redox score ?
82
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
129
Residue number B
141
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 129 of Vitamin K-dependent protein Z

Cysteine 141 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 203 and 219 (163 and 179 respectively in this structure).

Details

Redox score ?
80
PDB code
3f1s
Structure name
crystal structure of protein z complexed with protein z-dependent inhibitor
Structure deposition date
2008-10-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
203
Residue number B
219
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 203 of Vitamin K-dependent protein Z

Cysteine 219 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 173 and 281 (133 and 241 respectively in this structure).

Details

Redox score ?
78
PDB code
3f1s
Structure name
crystal structure of protein z complexed with protein z-dependent inhibitor
Structure deposition date
2008-10-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
173
Residue number B
281
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 173 of Vitamin K-dependent protein Z

Cysteine 281 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 96 and 102 (56 and 62 respectively in this structure).

Details

Redox score ?
74
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
96
Residue number B
102
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 96 of Vitamin K-dependent protein Z

Cysteine 102 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 111 and 122 (71 and 82 respectively in this structure).

Details

Redox score ?
74
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
111
Residue number B
122
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 111 of Vitamin K-dependent protein Z

Cysteine 122 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 137 and 141 (97 and 101 respectively in this structure).

Details

Redox score ?
71
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
137
Residue number B
141
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 137 of Vitamin K-dependent protein Z

Cysteine 141 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 96 and 122 (56 and 82 respectively in this structure).

Details

Redox score ?
70
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
96
Residue number B
122
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 96 of Vitamin K-dependent protein Z

Cysteine 122 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 102 and 111 (62 and 71 respectively in this structure).

Details

Redox score ?
68
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
102
Residue number B
111
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 102 of Vitamin K-dependent protein Z

Cysteine 111 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 111 and 113 (71 and 73 respectively in this structure).

Details

Redox score ?
68
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
111
Residue number B
113
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 111 of Vitamin K-dependent protein Z

Cysteine 113 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 91 and 96 (51 and 56 respectively in this structure).

Details

Redox score ?
64
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
91
Residue number B
96
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 91 of Vitamin K-dependent protein Z

Cysteine 96 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 129 and 137 (89 and 97 respectively in this structure).

Details

Redox score ?
63
PDB code
3f1s
Structure name
crystal structure of protein z complexed with protein z-dependent inhibitor
Structure deposition date
2008-10-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
129
Residue number B
137
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 129 of Vitamin K-dependent protein Z

Cysteine 137 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 96 and 113 (56 and 73 respectively in this structure).

Details

Redox score ?
62
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
96
Residue number B
113
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 96 of Vitamin K-dependent protein Z

Cysteine 113 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 141 and 150 (101 and 110 respectively in this structure).

Details

Redox score ?
61
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
141
Residue number B
150
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 141 of Vitamin K-dependent protein Z

Cysteine 150 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 91 and 111 (51 and 71 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
91
Residue number B
111
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 91 of Vitamin K-dependent protein Z

Cysteine 111 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 150 and 165 (110 and 125 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
150
Residue number B
165
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 150 of Vitamin K-dependent protein Z

Cysteine 165 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 129 and 150 (89 and 110 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
3f1s
Structure name
crystal structure of protein z complexed with protein z-dependent inhibitor
Structure deposition date
2008-10-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
129
Residue number B
150
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 129 of Vitamin K-dependent protein Z

Cysteine 150 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 137 and 165 (97 and 125 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
137
Residue number B
165
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 137 of Vitamin K-dependent protein Z

Cysteine 165 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 150 and 152 (110 and 112 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
3f1s
Structure name
crystal structure of protein z complexed with protein z-dependent inhibitor
Structure deposition date
2008-10-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
150
Residue number B
152
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 150 of Vitamin K-dependent protein Z

Cysteine 152 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 137 and 152 (97 and 112 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
137
Residue number B
152
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 137 of Vitamin K-dependent protein Z

Cysteine 152 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 102 and 122 (62 and 82 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
102
Residue number B
122
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 102 of Vitamin K-dependent protein Z

Cysteine 122 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 171 and 173 (131 and 133 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
171
Residue number B
173
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 171 of Vitamin K-dependent protein Z

Cysteine 173 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 165 and 173 (125 and 133 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
3f1s
Structure name
crystal structure of protein z complexed with protein z-dependent inhibitor
Structure deposition date
2008-10-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
165
Residue number B
173
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 165 of Vitamin K-dependent protein Z

Cysteine 173 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 173 and 273 (133 and 233 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
173
Residue number B
273
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 173 of Vitamin K-dependent protein Z

Cysteine 273 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 165 and 281 (125 and 241 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
3f1s
Structure name
crystal structure of protein z complexed with protein z-dependent inhibitor
Structure deposition date
2008-10-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
165
Residue number B
281
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 165 of Vitamin K-dependent protein Z

Cysteine 281 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 152 and 281 (112 and 241 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
3h5c
Structure name
x-ray structure of protein z-protein z inhibitor complex
Structure deposition date
2009-04-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
152
Residue number B
281
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 152 of Vitamin K-dependent protein Z

Cysteine 281 of Vitamin K-dependent protein Z

A redox-regulated disulphide may form within Vitamin K-dependent protein Z between cysteines 152 and 173 (112 and 133 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
3f1s
Structure name
crystal structure of protein z complexed with protein z-dependent inhibitor
Structure deposition date
2008-10-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22891
Residue number A
152
Residue number B
173
Peptide name
Vitamin K-dependent protein Z

Ligandability

Cysteine 152 of Vitamin K-dependent protein Z

Cysteine 173 of Vitamin K-dependent protein Z

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