ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Macrophage mannose receptor 1

Intramolecular
Cysteine 600 and cysteine 617
Cysteine 504 and cysteine 515
Cysteine 362 and cysteine 373
Cysteine 35 and cysteine 49
Cysteine 463 and cysteine 478
Cysteine 74 and cysteine 91
Cysteine 182 and cysteine 209
Cysteine 316 and cysteine 332
Cysteine 102 and cysteine 149
Cysteine 532 and cysteine 625
More...
Cysteine 753 and cysteine 769
Cysteine 680 and cysteine 777
Cysteine 646 and cysteine 659
Cysteine 247 and cysteine 340
Cysteine 168 and cysteine 194
Cysteine 391 and cysteine 486
Cysteine 168 and cysteine 209
Cysteine 168 and cysteine 182
Cysteine 194 and cysteine 209
Cysteine 182 and cysteine 194
Cysteine 209 and cysteine 659
A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 600 and 617.

Details

Redox score ?
85
PDB code
6inn
Structure name
crystal structure of the cysr-ctld3 fragment of human mr at acidic ph (ph 5
Structure deposition date
2018-10-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22897
Residue number A
600
Residue number B
617
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 600 of Macrophage mannose receptor 1

Cysteine 617 of Macrophage mannose receptor 1

A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 504 and 515.

Details

Redox score ?
85
PDB code
6inn
Structure name
crystal structure of the cysr-ctld3 fragment of human mr at acidic ph (ph 5
Structure deposition date
2018-10-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22897
Residue number A
504
Residue number B
515
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 504 of Macrophage mannose receptor 1

Cysteine 515 of Macrophage mannose receptor 1

A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 362 and 373.

Details

Redox score ?
84
PDB code
6inn
Structure name
crystal structure of the cysr-ctld3 fragment of human mr at acidic ph (ph 5
Structure deposition date
2018-10-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22897
Residue number A
362
Residue number B
373
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 362 of Macrophage mannose receptor 1

Cysteine 373 of Macrophage mannose receptor 1

A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 35 and 49.

Details

Redox score ?
83
PDB code
6ino
Structure name
crystal structure of the cysr-ctld2 fragment of human mr at acidic ph (ph 4
Structure deposition date
2018-10-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22897
Residue number A
35
Residue number B
49
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 35 of Macrophage mannose receptor 1

Cysteine 49 of Macrophage mannose receptor 1

A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 463 and 478.

Details

Redox score ?
83
PDB code
6inu
Structure name
crystal structure of the cysr-ctld2 fragment of human mr at acidic ph (ph 4
Structure deposition date
2018-10-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22897
Residue number A
463
Residue number B
478
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 463 of Macrophage mannose receptor 1

Cysteine 478 of Macrophage mannose receptor 1

A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 74 and 91.

Details

Redox score ?
83
PDB code
6inn
Structure name
crystal structure of the cysr-ctld3 fragment of human mr at acidic ph (ph 5
Structure deposition date
2018-10-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22897
Residue number A
74
Residue number B
91
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 74 of Macrophage mannose receptor 1

Cysteine 91 of Macrophage mannose receptor 1

A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 182 and 209.

Details

Redox score ?
83
PDB code
6inn
Structure name
crystal structure of the cysr-ctld3 fragment of human mr at acidic ph (ph 5
Structure deposition date
2018-10-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22897
Residue number A
182
Residue number B
209
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 182 of Macrophage mannose receptor 1

Cysteine 209 of Macrophage mannose receptor 1

A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 316 and 332.

Details

Redox score ?
83
PDB code
6inn
Structure name
crystal structure of the cysr-ctld3 fragment of human mr at acidic ph (ph 5
Structure deposition date
2018-10-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22897
Residue number A
316
Residue number B
332
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 316 of Macrophage mannose receptor 1

Cysteine 332 of Macrophage mannose receptor 1

A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 102 and 149.

Details

Redox score ?
83
PDB code
6ioe
Structure name
crystal structure of the cysr-ctld2 fragment of human mr at basic ph (ph 8
Structure deposition date
2018-10-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22897
Residue number A
102
Residue number B
149
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 102 of Macrophage mannose receptor 1

Cysteine 149 of Macrophage mannose receptor 1

A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 532 and 625.

Details

Redox score ?
82
PDB code
6inn
Structure name
crystal structure of the cysr-ctld3 fragment of human mr at acidic ph (ph 5
Structure deposition date
2018-10-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22897
Residue number A
532
Residue number B
625
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 532 of Macrophage mannose receptor 1

Cysteine 625 of Macrophage mannose receptor 1

A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 753 and 769 (735 and 751 respectively in this structure).

Details

Redox score ?
82
PDB code
7jud
Structure name
c-type carbohydrate-recognition domain 4 of the mannose receptor complexed with methyl-mannoside
Structure deposition date
2020-08-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22897
Residue number A
753
Residue number B
769
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 753 of Macrophage mannose receptor 1

Cysteine 769 of Macrophage mannose receptor 1

A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 680 and 777 (662 and 759 respectively in this structure).

Details

Redox score ?
82
PDB code
1egi
Structure name
structure of a c-type carbohydrate-recognition domain (crd- 4) from the macrophage mannose receptor
Structure deposition date
2000-02-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22897
Residue number A
680
Residue number B
777
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 680 of Macrophage mannose receptor 1

Cysteine 777 of Macrophage mannose receptor 1

A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 646 and 659 (628 and 641 respectively in this structure).

Details

Redox score ?
82
PDB code
1egg
Structure name
structure of a c-type carbohydrate-recognition domain (crd- 4) from the macrophage mannose receptor
Structure deposition date
2000-02-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22897
Residue number A
646
Residue number B
659
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 646 of Macrophage mannose receptor 1

Cysteine 659 of Macrophage mannose receptor 1

A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 247 and 340.

Details

Redox score ?
79
PDB code
6ino
Structure name
crystal structure of the cysr-ctld2 fragment of human mr at acidic ph (ph 4
Structure deposition date
2018-10-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22897
Residue number A
247
Residue number B
340
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 247 of Macrophage mannose receptor 1

Cysteine 340 of Macrophage mannose receptor 1

A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 168 and 194.

Details

Redox score ?
78
PDB code
6inn
Structure name
crystal structure of the cysr-ctld3 fragment of human mr at acidic ph (ph 5
Structure deposition date
2018-10-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22897
Residue number A
168
Residue number B
194
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 168 of Macrophage mannose receptor 1

Cysteine 194 of Macrophage mannose receptor 1

A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 391 and 486.

Details

Redox score ?
76
PDB code
6inv
Structure name
crystal structure of the cysr-ctld2 fragment of human mr at acidic ph (ph 4
Structure deposition date
2018-10-27
Thiol separation (Å)
3
Half-sphere exposure sum ?
72
Minimum pKa ?
8
% buried
77
Peptide accession
P22897
Residue number A
391
Residue number B
486
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 391 of Macrophage mannose receptor 1

Cysteine 486 of Macrophage mannose receptor 1

A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 168 and 209.

Details

Redox score ?
69
PDB code
6inn
Structure name
crystal structure of the cysr-ctld3 fragment of human mr at acidic ph (ph 5
Structure deposition date
2018-10-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22897
Residue number A
168
Residue number B
209
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 168 of Macrophage mannose receptor 1

Cysteine 209 of Macrophage mannose receptor 1

A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 168 and 182.

Details

Redox score ?
69
PDB code
6ioe
Structure name
crystal structure of the cysr-ctld2 fragment of human mr at basic ph (ph 8
Structure deposition date
2018-10-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22897
Residue number A
168
Residue number B
182
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 168 of Macrophage mannose receptor 1

Cysteine 182 of Macrophage mannose receptor 1

A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 194 and 209.

Details

Redox score ?
66
PDB code
6ioe
Structure name
crystal structure of the cysr-ctld2 fragment of human mr at basic ph (ph 8
Structure deposition date
2018-10-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22897
Residue number A
194
Residue number B
209
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 194 of Macrophage mannose receptor 1

Cysteine 209 of Macrophage mannose receptor 1

A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 182 and 194.

Details

Redox score ?
63
PDB code
6inu
Structure name
crystal structure of the cysr-ctld2 fragment of human mr at acidic ph (ph 4
Structure deposition date
2018-10-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22897
Residue number A
182
Residue number B
194
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 182 of Macrophage mannose receptor 1

Cysteine 194 of Macrophage mannose receptor 1

A redox-regulated disulphide may form within Macrophage mannose receptor 1 between cysteines 209 and 659 (628 and 641 respectively in this structure).

Details

Redox score ?
nan
PDB code
7l66
Structure name
c-type carbohydrate-recognition domain 4 of the mannose receptor complexed with methyl-glcnac
Structure deposition date
2020-12-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P22897
Residue number A
209
Residue number B
659
Peptide name
Macrophage mannose receptor 1

Ligandability

Cysteine 209 of Macrophage mannose receptor 1

Cysteine 659 of Macrophage mannose receptor 1

Uncertain whether structure cysteine 628 has been assigned to correct residue.
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